Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2021 Jan 8

PMID 33415105

Citations 51

Authors

Kaixuan Chen

Yurui Jiao

Ling Liu

Mei Huang

Chen He

Wenzhen He

Jing Hou

Mi Yang

Xianghang Luo

Changjun Li

Affiliations

Soon will be listed here.

Abstract

The mammalian skeleton is a metabolically active organ that continuously undergoes bone remodeling, a process of tightly coupled bone resorption and formation throughout life. Recent studies have expanded our knowledge about the interactions between cells within bone marrow in bone remodeling. Macrophages resident in bone (BMMs) can regulate bone metabolism via secreting numbers of cytokines and exosomes. This review summarizes the current understanding of factors, exosomes, and hormones that involved in the communications between BMMs and other bone cells including mensenchymal stem cells, osteoblasts, osteocytes, and so on. We also discuss the role of BMMs and potential therapeutic approaches targeting BMMs in bone remodeling related diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma.

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