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Use of Stem-cell Sheets Expressing Bone Morphogenetic Protein-7 in the Management of a Nonunion Radial Fracture in a Toy Poodle

Overview
Journal J Vet Sci
Specialty Veterinary Medicine
Date 2017 Apr 8
PMID 28385008
Citations 2
Authors
Jaeyong Song
Yongsun Kim
Oh-Kyeong Kweon
Byung-Jae Kang
Affiliations
Soon will be listed here.
Abstract

A 12-year-old castrated Toy Poodle was referred to the Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the distal 1/3 of the left radius and an intact ulna. After fixation by a locking plate and screws, adipose-derived mesenchymal stem-cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture was healed at 9 weeks after surgery. In the present case, the mesenchymal stem-cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.

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Clinical Application of Adipose Derived Stem Cells for the Treatment of Aseptic Non-Unions: Current Stage and Future Perspectives-Systematic Review.

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PMID: 35328476 PMC: 8950719. DOI: 10.3390/ijms23063057.

Bone morphogenetic protein-7 upregulates genes associated with osteoblast differentiation, including collagen I, Sp7 and IBSP in gingiva-derived stem cells.

Lee H, Min S, Song Y, Park Y, Park J Exp Ther Med. 2019; 18(4):2867-2876.

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