An Updated Review of Cribriform Carcinomas with Emphasis on Histopathological Diagnosis and Prognostic Significance

Overview

Journal Oncol Rev

Specialty Oncology

Date 2017 Apr 7

PMID 28382188

Citations 15

Authors

Giovanni Branca

Antonio Ieni

Valeria Barresi

Giovanni Tuccari

Rosario Alberto Caruso

Affiliations

Soon will be listed here.

Abstract

Cribriform is a histopathological term used to describe a neoplastic epithelial proliferation in the form of large nests perforated by many quite rounded different-sized spaces. This growth pattern may be seen in carcinomas arising in different organs, and shows important prognostic implications. Therefore, recent data in literature suggest that cribriform carcinoma is a histologically and clinically distinctive type of tumour that should be separated from other similar tumour types. In this article, the pathology of cribriform adenocarcinoma of the prostate, lung, breast, stomach, colon, thyroid, and skin is discussed with particular reference to morphologic and immunohistochemical features, differential diagnosis, and clinical behaviour.

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