Morphology and Molecular Features of Rare Colorectal Carcinoma Histotypes

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2019 Jul 26

PMID 31340478

Citations 33

Authors

Andrea Remo

Matteo Fassan

Alessandro Vanoli

Luca Reggiani Bonetti

Valeria Barresi

Fabiana Tatangelo

Roberta Gafa

Guido Giordano

Massimo Pancione

Federica Grillo

Luca Mastracci

Affiliations

Soon will be listed here.

Abstract

Several histopathological variants of colorectal carcinoma can be distinguished, some associated with specific molecular profiles. However, in routine practice, ninety/ninety-five percent of all large bowel tumors are diagnosed as conventional adenocarcinoma, even though they are a heterogeneous group including rare histotypes, which are often under-recognized. Indeed, colorectal cancer exhibits differences in incidence, location of tumor, pathogenesis, molecular pathways and outcome depending on histotype. The aim is therefore to review the morphological and molecular features of these rare variants of intestinal carcinomas which may hold the key to differences in prognosis and treatment.

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