Mitochondrial Protein Import Under Kinase Surveillance

Overview

Journal Microb Cell

Specialty Microbiology

Date 2017 Mar 31

PMID 28357222

Citations 6

Authors

Magdalena Opalinska

Chris Meisinger

Affiliations

Soon will be listed here.

Abstract

Despite the simplicity of the yeast its basic cellular machinery tremendously mirrors that of higher eukaryotic counterparts. Thus, this unicellular organism turned out to be an invaluable model system to study the countless mechanisms that govern life of the cell. Recently, it has also enabled the deciphering of signalling pathways that control flux of mitochondrial proteins to the organelle according to metabolic requirements. For decades mitochondria were considered autonomous organelles that are only partially incorporated into cellular signalling networks. Consequently, only little has been known about the role of reversible phosphorylation as a meaningful mechanism that orchestrates mitochondrial biology accordingly to cellular needs. Therefore, research in this direction has been vastly neglected. However, findings over the past few years have changed this view and new exciting fields in mitochondrial biology have emerged. Here, we summarize recent discoveries in the yeast model system that point towards a vital role of reversible phosphorylation in regulation of mitochondrial protein import.

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References

Pagliarini D, Calvo S, Chang B, Sheth S, Vafai S, Ong S . A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008; 134(1):112-23. PMC: 2778844. DOI: 10.1016/j.cell.2008.06.016. View

Cohen P . Protein kinases--the major drug targets of the twenty-first century?. Nat Rev Drug Discov. 2002; 1(4):309-15. DOI: 10.1038/nrd773. View

Vancura A, Sessler A, Leichus B, Kuret J . A prenylation motif is required for plasma membrane localization and biochemical function of casein kinase I in budding yeast. J Biol Chem. 1994; 269(30):19271-8. View

Rao S, Gerbeth C, Harbauer A, Mikropoulou D, Meisinger C, Schmidt O . Signaling at the gate: phosphorylation of the mitochondrial protein import machinery. Cell Cycle. 2011; 10(13):2083-90. DOI: 10.4161/cc.10.13.16054. View

Stojanovski D, Muller J, Milenkovic D, Guiard B, Pfanner N, Chacinska A . The MIA system for protein import into the mitochondrial intermembrane space. Biochim Biophys Acta. 2007; 1783(4):610-7. DOI: 10.1016/j.bbamcr.2007.10.004. View

Newmeyer D, Ferguson-Miller S . Mitochondria: releasing power for life and unleashing the machineries of death. Cell. 2003; 112(4):481-90. DOI: 10.1016/s0092-8674(03)00116-8. View

Schmidt O, Pfanner N, Meisinger C . Mitochondrial protein import: from proteomics to functional mechanisms. Nat Rev Mol Cell Biol. 2010; 11(9):655-67. DOI: 10.1038/nrm2959. View

Sickmann A, Reinders J, Wagner Y, Joppich C, Zahedi R, Meyer H . The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A. 2003; 100(23):13207-12. PMC: 263752. DOI: 10.1073/pnas.2135385100. View

Olsten M, Litchfield D . Order or chaos? An evaluation of the regulation of protein kinase CK2. Biochem Cell Biol. 2005; 82(6):681-93. DOI: 10.1139/o04-116. View

10.

Hunter T . Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell. 1995; 80(2):225-36. DOI: 10.1016/0092-8674(95)90405-0. View

11.

Dimmer K, Rapaport D . Unresolved mysteries in the biogenesis of mitochondrial membrane proteins. Biochim Biophys Acta. 2011; 1818(4):1085-90. DOI: 10.1016/j.bbamem.2011.08.027. View

12.

Pagliarini D, Dixon J . Mitochondrial modulation: reversible phosphorylation takes center stage?. Trends Biochem Sci. 2005; 31(1):26-34. DOI: 10.1016/j.tibs.2005.11.005. View

13.

Green D, Kroemer G . The pathophysiology of mitochondrial cell death. Science. 2004; 305(5684):626-9. DOI: 10.1126/science.1099320. View

14.

Endo T, Yamano K, Kawano S . Structural basis for the disulfide relay system in the mitochondrial intermembrane space. Antioxid Redox Signal. 2010; 13(9):1359-73. DOI: 10.1089/ars.2010.3099. View

15.

Tomaska L . Mitochondrial protein phosphorylation: lessons from yeasts. Gene. 2000; 255(1):59-64. DOI: 10.1016/s0378-1119(00)00315-2. View

16.

Becker T, Vogtle F, Stojanovski D, Meisinger C . Sorting and assembly of mitochondrial outer membrane proteins. Biochim Biophys Acta. 2008; 1777(7-8):557-63. DOI: 10.1016/j.bbabio.2008.03.017. View

17.

Breitkreutz A, Choi H, Sharom J, Boucher L, Neduva V, Larsen B . A global protein kinase and phosphatase interaction network in yeast. Science. 2010; 328(5981):1043-6. PMC: 3983991. DOI: 10.1126/science.1176495. View

18.

Kutik S, Stojanovski D, Becker L, Becker T, Meinecke M, Kruger V . Dissecting membrane insertion of mitochondrial beta-barrel proteins. Cell. 2008; 132(6):1011-24. DOI: 10.1016/j.cell.2008.01.028. View

19.

Qiu J, Wenz L, Zerbes R, Oeljeklaus S, Bohnert M, Stroud D . Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell. 2013; 154(3):596-608. DOI: 10.1016/j.cell.2013.06.033. View

20.

Reinders J, Wagner K, Zahedi R, Stojanovski D, Eyrich B, van der Laan M . Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics. 2007; 6(11):1896-906. DOI: 10.1074/mcp.M700098-MCP200. View