Mitochondrial Protein Import: from Proteomics to Functional Mechanisms

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2010 Aug 24

PMID 20729931

Citations 356

Authors

Oliver Schmidt

Nikolaus Pfanner

Chris Meisinger

Affiliations

Soon will be listed here.

Abstract

Mitochondria contain approximately 1,000 different proteins, most of which are imported from the cytosol. Two import pathways that direct proteins into the mitochondrial inner membrane and matrix have been known for many years. The identification of numerous new transport components in recent proteomic studies has led to novel mechanistic insight into these pathways and the discovery of new import pathways into the outer membrane and intermembrane space. Protein translocases do not function as independent units but are integrated into dynamic networks and are connected to machineries that function in bioenergetics, mitochondrial morphology and coupling to the endoplasmic reticulum.

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