The Role of Macrophage Lipophagy in Reverse Cholesterol Transport

Overview

Journal Endocrinol Metab (Seoul)

Specialty Endocrinology

Date 2017 Mar 28

PMID 28345315

Citations 18

Authors

Se Jin Jeong

Mi Ni Lee

Goo Taeg Oh

Affiliations

Soon will be listed here.

Abstract

Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.

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