Para-Selective C-H Borylation of (Hetero)Arenes by Cooperative Iridium/Aluminum Catalysis

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2017 Mar 28

PMID 28345205

Citations 32

Authors

Lichen Yang

Kazuhiko Semba

Yoshiaki Nakao

Affiliations

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Abstract

para-Selective C-H borylation of benzamides and pyridines has been achieved by cooperative iridium/aluminum catalysis. A combination of iridium catalysts commonly employed for arene C-H borylation and bulky aluminum-based Lewis acid catalysts provides an unprecedented strategy for controlling the regioselectivity of C-H borylation to give variously substituted (hetero)arylboronates, which are versatile synthetic intermediates for complex multi-substituted aromatic compounds.

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