Parkinson's Disease-associated Receptor GPR37 is an ER Chaperone for LRP6

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2017 Mar 26

PMID 28341812

Citations 22

Authors

Birgit S Berger

Sergio P Acebron

Jessica Herbst

Stefan Koch

Christof Niehrs

Affiliations

Soon will be listed here.

Abstract

Wnt/β-catenin signaling plays a key role in embryonic development, stem cell biology, and neurogenesis. However, the mechanisms of Wnt signal transmission, notably how the receptors are regulated, remain incompletely understood. Here we describe that the Parkinson's disease-associated receptor GPR37 functions in the maturation of the N-terminal bulky β-propellers of the Wnt co-receptor LRP6. GPR37 is required for Wnt/β-catenin signaling and protects LRP6 from ER-associated degradation via CHIP (carboxyl terminus of Hsc70-interacting protein) and the ATPase VCP GPR37 is highly expressed in neural progenitor cells (NPCs) where it is required for Wnt-dependent neurogenesis. We conclude that GPR37 is crucial for cellular protein quality control during Wnt signaling.

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