Consciousness Loss During Epileptogenesis: Implication for VLPO-PnO Circuits

Overview

Journal Int J Physiol Pathophysiol Pharmacol

Date 2017 Mar 25

PMID 28337311

Citations 4

Authors

Maohui Feng

Zhigang He

Baowen Liu

Zhixiao Li

Guorong Tao

Duozhi Wu

Hongbing Xiang

Affiliations

Soon will be listed here.

Abstract

There is a growing concern about consciousness loss during epileptic seizures. Understanding neural mechanisms could lead to a better comprehension of cerebral circuit function in the control of consciousness loss in intractable epilepsy. We propose that ventrolateral preoptic area (VLPO)- PnO (nucleus pontis oralis) circuits may serve a major role in the loss of consciousness in drug-refractory epilepsy. Future behavioural and neuroimaging studies are clearly needed to understand the functional connectivity between the VLPO and PnO during loss of consciousness in drug-refractory epilepsy, to greatly prevent unconsciousness in this disorder and improve the quality of life in patients with intractable epilepsy.

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