Cross Interaction of Melanocortinergic and Dopaminergic Systems in Neural Modulation

Overview

Journal Int J Physiol Pathophysiol Pharmacol

Date 2016 Jan 30

PMID 26823964

Citations 7

Authors

Zhi-Gang He

Bao-Wen Liu

Hong-Bing Xiang

Affiliations

Soon will be listed here.

Abstract

Melanocortinergic and dopaminergic systems are widely distributed in the CNS and have been established as a crucial regulatory component in diverse physiological functions. The pharmacology of both melanocortinergic and dopaminergic systems including their individual receptors, signaling mechanisms, agonists and antagonists has been extensively studied. Several lines of evidence showed that there existed a cross interaction between the receptors of melanocortinergic and dopaminergic systems. The data available at present had expanded our understanding of melanocortinergic and dopaminergic system interaction in neural modulation, which will be main discussed in this paper.

Citing Articles

How does oxytocin modulate human behavior?.

Yao S, Kendrick K Mol Psychiatry. 2025; .

PMID: 39827220 DOI: 10.1038/s41380-025-02898-1.

Motivational dysregulation with melanocortin 4 receptor haploinsufficiency.

Steiner A, Roscoe Jr R, Booze R, Mactutus C NeuroImmune Pharm Ther. 2025; 3(3-4):237-250.

PMID: 39741559 PMC: 11683877. DOI: 10.1515/nipt-2024-0011.

Photophysical Mechanisms of Photobiomodulation Therapy as Precision Medicine.

Liebert A, Capon W, Pang V, Vila D, Bicknell B, McLachlan C Biomedicines. 2023; 11(2).

PMID: 36830774 PMC: 9953702. DOI: 10.3390/biomedicines11020237.

Neuroanatomical autonomic substrates of brainstem-gut circuitry identified using transsynaptic tract-tracing with pseudorabies virus recombinants.

He Z, Wang Q, Xie R, Li Y, Hong Q, Xiang H Am J Clin Exp Immunol. 2018; 7(2):16-24.

PMID: 29755854 PMC: 5944814.

One case with dexmedetomidine-induced stuporous state in epileptic patient undergoing abdominal surgery.

Han D, He Z, Zhou Z, Feng L, Liu C, Xiang Y Am J Neurodegener Dis. 2017; 6(3):26-31.

PMID: 28804692 PMC: 5545215.

References

Zhou Q, Chen J, Yi S, Lou Y, Tang W, Liu Y . Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats. Neural Regen Res. 2015; 7(27):2107-14. PMC: 4281411. DOI: 10.3969/j.issn.1673-5374.2012.27.004. View

Hao Y, Tian X, Liu C, Xiang H . Retrograde tracing of medial vestibular nuclei connections to the kidney in mice. Int J Clin Exp Pathol. 2014; 7(8):5348-54. PMC: 4152112. View

Xiang H, Liu C, Guo Q, Li R, Ye D . Deep brain stimulation of the pedunculopontine tegmental nucleus may influence renal function. Med Hypotheses. 2011; 77(6):1135-8. DOI: 10.1016/j.mehy.2011.09.022. View

Cui H, Sohn J, Gautron L, Funahashi H, Williams K, Elmquist J . Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area. J Comp Neurol. 2012; 520(18):4168-83. PMC: 3652326. DOI: 10.1002/cne.23145. View

Schwartz M, Seeley R, Woods S, Weigle D, Campfield L, Burn P . Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 1997; 46(12):2119-23. DOI: 10.2337/diab.46.12.2119. View

Ford C, Mark G, Williams J . Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. J Neurosci. 2006; 26(10):2788-97. PMC: 3623681. DOI: 10.1523/JNEUROSCI.4331-05.2006. View

Lippert R, Ellacott K, Cone R . Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice. Endocrinology. 2014; 155(5):1718-27. PMC: 3990839. DOI: 10.1210/en.2013-2049. View

Ye D, Liu C, Liu T, Tian X, Xiang H . Motor cortex-periaqueductal gray-spinal cord neuronal circuitry may involve in modulation of nociception: a virally mediated transsynaptic tracing study in spinally transected transgenic mouse model. PLoS One. 2014; 9(2):e89486. PMC: 3929690. DOI: 10.1371/journal.pone.0089486. View

Liu H, Kishi T, Roseberry A, Cai X, Lee C, Montez J . Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci. 2003; 23(18):7143-54. PMC: 6740648. View

10.

Margolis E, Coker A, Driscoll J, Lemaitre A, Fields H . Reliability in the identification of midbrain dopamine neurons. PLoS One. 2010; 5(12):e15222. PMC: 3000317. DOI: 10.1371/journal.pone.0015222. View

11.

Ye D, Liu C, Tian X, Xiang H . Identification of neuroanatomic circuits from spinal cord to stomach in mouse: retrograde transneuronal viral tracing study. Int J Clin Exp Pathol. 2014; 7(8):5343-7. PMC: 4152111. View

12.

Millington G . The role of proopiomelanocortin (POMC) neurones in feeding behaviour. Nutr Metab (Lond). 2007; 4:18. PMC: 2018708. DOI: 10.1186/1743-7075-4-18. View

13.

Pan X, Song Y, Liu C, Xiang H, Lu C . Melanocortin-4 receptor expression in the rostral ventromedial medulla involved in modulation of nociception in transgenic mice. J Huazhong Univ Sci Technolog Med Sci. 2013; 33(2):195-198. DOI: 10.1007/s11596-013-1096-9. View

14.

Doyon W, Thomas A, Ostroumov A, Dong Y, Dani J . Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system. Biochem Pharmacol. 2013; 86(8):1181-93. PMC: 3800178. DOI: 10.1016/j.bcp.2013.07.007. View

15.

Xiang H, Liu C, Liu T, Xiong J . Central circuits regulating the sympathetic outflow to lumbar muscles in spinally transected mice by retrograde transsynaptic transport. Int J Clin Exp Pathol. 2014; 7(6):2987-97. PMC: 4097212. View

16.

Luquin M, Montoro R, Guillen J, Saldise L, Insausti R, Del Rio J . Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen. Neuron. 1999; 22(4):743-50. DOI: 10.1016/s0896-6273(00)80733-3. View

17.

Thomas M, Malenka R . Synaptic plasticity in the mesolimbic dopamine system. Philos Trans R Soc Lond B Biol Sci. 2003; 358(1432):815-9. PMC: 1693149. DOI: 10.1098/rstb.2002.1236. View

18.

Alvaro J, Tatro J, Quillan J, Fogliano M, Eisenhard M, Lerner M . Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Mol Pharmacol. 1996; 50(3):583-91. View

19.

Norgren R, Hajnal A, Mungarndee S . Gustatory reward and the nucleus accumbens. Physiol Behav. 2006; 89(4):531-5. PMC: 3114426. DOI: 10.1016/j.physbeh.2006.05.024. View

20.

Lim B, Huang K, Grueter B, Rothwell P, Malenka R . Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens. Nature. 2012; 487(7406):183-9. PMC: 3397405. DOI: 10.1038/nature11160. View