Salivary Microbiota in Individuals with Different Levels of Caries Experience

Overview

Journal J Oral Microbiol

Specialty Dentistry

Date 2017 Mar 23

PMID 28326153

Citations 34

Authors

Daniel Belstrom

Palle Holmstrup

Nils-Erik Fiehn

Nikolai Kirkby

Alexis Kokaras

Bruce J Paster

Allan Bardow

Affiliations

Soon will be listed here.

Abstract

This study compared salivary bacterial profiles in two groups having a 10-fold difference in levels of caries experience, as it was hypothesized that the composition of the salivary microbiota might associate with the levels of caries experience. Bacterial profiles in stimulated saliva samples from 85 individuals with low levels of caries experience (healthy group) and 79 individuals with high levels of caries experience (caries group) were analyzed by means of the Human Oral Microbiome Identification Next Generation Sequencing (HOMI) technique. Subsequently, saliva samples from caries-free individuals in the healthy group ( = 57) and the caries group ( = 31) were compared. A significantly higher α-diversity ( < 0.0001) and a twofold higher relative abundance of , , and were recorded in saliva samples from the healthy group compared with the caries group. Differences observed were more pronounced when limiting the analyses to caries-free individuals in each group. Data from this cross-sectional analysis suggest that low levels of caries experience might associate with a characteristic salivary bacterial composition different from that in individuals with high caries experience. Consequently, longitudinal studies are required to determine if the composition of the salivary microbiota might be a predictive factor of caries risk at the individual level.

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