Anti-obesity Effect of Var. Extract Through Regulation of Adipogenesis and Lipogenesis Pathways in High-fat Diet-induced Obese Mice (C57BL/6N)

Overview

Journal Food Nutr Res

Specialty Nutritional Sciences

Date 2017 Mar 23

PMID 28326002

Citations 15

Authors

Zhiqiang Wang

Ju Hee Kim

Young Soo Jang

Chea Ha Kim

Jae-Yong Lee

Soon Sung Lim

Affiliations

Soon will be listed here.

Abstract

Obesity is associated with an increase in adipogenesis and is becoming a serious health problem in modern society. The effects of various Solidago virgaurea var. gigantean (SV) ethanolic aqueous extracts on anti-adipogenesis in 3T3-L1 cells were investigated. In addition, the effect of SV 10% ethanolic extract (SV10E) on preventing obesity was studied in high-fat diet-induced obese mice (C57BL/6 N). The effect of SV10E on preventing obesity was studied in mice (n = 6): normal-fat diet, high-fat diet (HFD), HFD supplemented with 1% (10 g/kg) Garcinia cambogia extract of 60% (-)-hydroxycitric acid (positive control), HFD supplemented with 0.5% (5 g/kg) SV10E, and HFD supplemented with 2% (20 g/kg) SV10E. SV10E showed the highest anti-adipogenic activity in vitro and reduced body weight gain, adipose tissue size, and liver weight, without affecting food intake in vivo. SV10E administration decreased the levels of total triacylglycerol and cholesterol in serum, and lipid metabolites in liver. Adipogenic and lipogenic genes such as PPAR-γ, C/EBP-α, aP2, FAS, SCD-1, SREBP-1c, and CD36 in white adipose tissue and liver were suppressed by SV10E administration. SV10E can be a potent functional food ingredient for preventing HFD-induced obesity by suppressing adipogenesis and lipogenesis.

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