Thymic Lymphoma Induction by the AKT8 Murine Retrovirus

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1988 Mar 1

PMID 2832508

Citations 24

Authors

S P Staal

J W Hartley

Affiliations

Soon will be listed here.

Abstract

The directly transforming murine retrovirus, AKT8, was isolated from a spontaneous AKR thymoma and carries the cell-derived viral oncogene, akt. We have now shown that this virus produces thymic lymphomas after inoculation of susceptible mouse strains. The presence of the AKT8 genome in the DNA of the virus-induced tumors was demonstrated by Southern blotting using an akt-specific probe. These results establish the in vivo pathogenicity of the AKT8 virus and its akt oncogene, and imply a potential role for the cellular akt proto-oncogene in tumor development.

Citing Articles

PI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (Review).

Xie Y, Shi X, Sheng K, Han G, Li W, Zhao Q Mol Med Rep. 2018; 19(2):783-791.

PMID: 30535469 PMC: 6323245. DOI: 10.3892/mmr.2018.9713.

Murine Endogenous Retroviruses Are Detectable in Patient-Derived Xenografts but Not in Patient-Individual Cell Lines of Human Colorectal Cancer.

Bock S, Mullins C, Klar E, Perot P, Maletzki C, Linnebacher M Front Microbiol. 2018; 9:789.

PMID: 29755432 PMC: 5932414. DOI: 10.3389/fmicb.2018.00789.

Presence of a Shared 5'-Leader Sequence in Ancestral Human and Mammalian Retroviruses and Its Transduction into Feline Leukemia Virus.

Kawasaki J, Kawamura M, Ohsato Y, Ito J, Nishigaki K J Virol. 2017; 91(20).

PMID: 28768854 PMC: 5625498. DOI: 10.1128/JVI.00829-17.

Modulation of nuclear factor-ϰB by human T cell leukemia virus type 1 tax protein : Implications for oncogenesis and inflammation.

Peloponese Jr J, Yeung M, Jeang K Immunol Res. 2016; 34(1):1-12.

PMID: 27519575 DOI: 10.1385/IR:34:1:1.

PI3K/AKT Pathway and Its Mediators in Thyroid Carcinomas.

Nozhat Z, Hedayati M Mol Diagn Ther. 2015; 20(1):13-26.

PMID: 26597586 DOI: 10.1007/s40291-015-0175-y.

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