Inhibition of Superoxide Anion Production in Guinea Pig Polymorphonuclear Leukocytes by a Seleno-organic Compound, Ebselen

Overview

Journal J Pharmacobiodyn

Specialty Pharmacology

Date 1987 Oct 1

PMID 2831335

Citations 7

Authors

S Ichikawa

K Omura

T Katayama

N Okamura

T Ohtsuka

S Ishibashi

H Masayasu

Affiliations

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Abstract

Production of superoxide anion (O2-) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O2- production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.

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