The Pharmacology of Ebselen

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1991 Jan 1

PMID 2058468

Citations 9

Authors

M J Parnham

S Leyck

E Graf

E J Dowling

D R Blake

Affiliations

Soon will be listed here.

Citing Articles

Toxicology and pharmacology of synthetic organoselenium compounds: an update.

Nogueira C, Barbosa N, Rocha J Arch Toxicol. 2021; 95(4):1179-1226.

PMID: 33792762 PMC: 8012418. DOI: 10.1007/s00204-021-03003-5.

Potential therapeutic use of ebselen for COVID-19 and other respiratory viral infections.

Sies H, Parnham M Free Radic Biol Med. 2020; 156:107-112.

PMID: 32598985 PMC: 7319625. DOI: 10.1016/j.freeradbiomed.2020.06.032.

Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications.

Parnham M Inflamm Res. 2016; 66(1):1-12.

PMID: 27682578 DOI: 10.1007/s00011-016-0988-0.

Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.

Hanavan P, Borges C, Katchman B, Faigel D, Ho T, Ma C Oncotarget. 2015; 6(21):18418-28.

PMID: 26158899 PMC: 4621900. DOI: 10.18632/oncotarget.4099.

Toll-like receptor 4-mediated nuclear factor kappa B activation is essential for sensing exogenous oxidants to propagate and maintain oxidative/nitrosative cellular stress.

Karki R, Igwe O PLoS One. 2013; 8(9):e73840.

PMID: 24058497 PMC: 3776800. DOI: 10.1371/journal.pone.0073840.

References

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Kuhl P, Borbe H, Fischer H, Romer A, Safayhi H . Ebselen reduces the formation of LTB4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer. Prostaglandins. 1986; 31(6):1029-48. DOI: 10.1016/0090-6980(86)90207-8. View

Leyck S, Parnham M . Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen. Agents Actions. 1990; 30(3-4):426-31. DOI: 10.1007/BF01966308. View

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Niederau C, Ude K, Niederau M, Luthen R, Strohmeyer G, Ferrell L . Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis. Pancreas. 1991; 6(3):282-90. DOI: 10.1097/00006676-199105000-00005. View

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Ichikawa S, Omura K, Katayama T, Okamura N, Ohtsuka T, Ishibashi S . Inhibition of superoxide anion production in guinea pig polymorphonuclear leukocytes by a seleno-organic compound, ebselen. J Pharmacobiodyn. 1987; 10(10):595-7. DOI: 10.1248/bpb1978.10.595. View

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Cotgreave I, Duddy S, Kass G, Thompson D, Moldeus P . Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?. Biochem Pharmacol. 1989; 38(4):649-56. DOI: 10.1016/0006-2952(89)90211-6. View

13.

Beil W, Staar U, SEWING K . Interaction of the anti-inflammatory seleno-organic compound ebselen with acid secretion in isolated parietal cells and gastric H+/K(+)-ATPase. Biochem Pharmacol. 1990; 40(9):1997-2003. DOI: 10.1016/0006-2952(90)90229-e. View

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Safayhi H, Tiegs G, Wendel A . A novel biologically active seleno-organic compound--V. Inhibition by ebselen (PZ 51) of rat peritoneal neutrophil lipoxygenase. Biochem Pharmacol. 1985; 34(15):2691-4. DOI: 10.1016/0006-2952(85)90569-6. View

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Gimbrone Jr M, Brock A, Schafer A . Leukotriene B4 stimulates polymorphonuclear leukocyte adhesion to cultured vascular endothelial cells. J Clin Invest. 1984; 74(4):1552-5. PMC: 425327. DOI: 10.1172/JCI111570. View

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Wendel A, Tiegs G . A novel biologically active seleno-organic compound--VI. Protection by ebselen (PZ 51) against galactosamine/endotoxin-induced hepatitis in mice. Biochem Pharmacol. 1986; 35(13):2115-8. DOI: 10.1016/0006-2952(86)90578-2. View

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Fischer H, Terlinden R, Lohr J, Romer A . A novel biologically active selenoorganic compound. VIII. Biotransformation of ebselen. Xenobiotica. 1988; 18(12):1347-59. DOI: 10.3109/00498258809042259. View

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Varani J, Ginsburg I, Schuger L, GIBBS D, Bromberg J, Johnson K . Endothelial cell killing by neutrophils. Synergistic interaction of oxygen products and proteases. Am J Pathol. 1989; 135(3):435-8. PMC: 1879871. View

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Ager A, Gordon J . Differential effects of hydrogen peroxide on indices of endothelial cell function. J Exp Med. 1984; 159(2):592-603. PMC: 2187215. DOI: 10.1084/jem.159.2.592. View