Alpha-lipoic Acid (ALA) As a Supplementation for Weight Loss: Results from a Meta-analysis of Randomized Controlled Trials

Overview

Journal Obes Rev

Specialty Endocrinology

Date 2017 Mar 16

PMID 28295905

Citations 27

Authors

S Kucukgoncu

E Zhou

K B Lucas

C Tek

Affiliations

Soon will be listed here.

Abstract

Objectives: Obesity is associated with significant morbidity and mortality rates. Even modest weight loss may be associated with health benefits. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant. Studies have suggested anti-obesity properties of ALA; however, results are inconsistent. The purpose of this study is to conduct a meta-analysis of the effect of ALA on weight and body mass index (BMI).

Methods: A comprehensive, systematic literature search identified 10 articles on randomized, double-blind, placebo-controlled studies involving ALA. We conducted a meta-analysis of mean weight and BMI change differences between ALA and placebo treatment groups.

Results: Alpha-lipoic acid treatment coincided with a statistically significant 1.27 kg (confidence interval = 0.25 to 2.29) greater mean weight loss compared with the placebo group. A significant overall mean BMI difference of -0.43 kg/ m (confidence interval = -0.82 to -0.03) was found between the ALA and placebo groups. Meta-regression analysis showed no significance in ALA dose on BMI and weight changes. Study duration significantly affected BMI change, but not weight change.

Conclusions: Alpha-lipoic acid treatment showed small, yet significant short-term weight loss compared with placebo. Further research is needed to examine the effect of different doses and the long-term benefits of ALA on weight management.

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References

Mohammadi V, Khalili M, Eghtesadi S, Dehghani S, Jazayeri S, Aghababaee S . The effect of alpha-lipoic acid (ALA) supplementation on cardiovascular risk factors in men with chronic spinal cord injury: a clinical trial. Spinal Cord. 2015; 53(8):646. DOI: 10.1038/sc.2015.63. View

Koh E, Lee W, Lee S, Kim E, Cho E, Jeong E . Effects of alpha-lipoic Acid on body weight in obese subjects. Am J Med. 2010; 124(1):85.e1-8. DOI: 10.1016/j.amjmed.2010.08.005. View

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009; 62(10):1006-12. DOI: 10.1016/j.jclinepi.2009.06.005. View

Prieto-Hontoria P, Perez-Matute P, Fernandez-Galilea M, Barber A, Martinez J, Moreno-Aliaga M . Lipoic acid prevents body weight gain induced by a high fat diet in rats: effects on intestinal sugar transport. J Physiol Biochem. 2009; 65(1):43-50. DOI: 10.1007/BF03165968. View

McNeilly A, Davison G, Murphy M, Nadeem N, Trinick T, Duly E . Effect of α-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance. Lipids Health Dis. 2011; 10:217. PMC: 3268114. DOI: 10.1186/1476-511X-10-217. View

Wang Y, Li X, Guo Y, Chan L, Guan X . alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism. 2009; 59(7):967-76. PMC: 2882509. DOI: 10.1016/j.metabol.2009.10.018. View

Goldstein D . Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord. 1992; 16(6):397-415. View

Ziegler D, Ametov A, Barinov A, Dyck P, Gurieva I, Low P . Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care. 2006; 29(11):2365-70. DOI: 10.2337/dc06-1216. View

Prieto-Hontoria P, Perez-Matute P, Fernandez-Galilea M, Martinez J, Moreno-Aliaga M . Lipoic acid inhibits leptin secretion and Sp1 activity in adipocytes. Mol Nutr Food Res. 2011; 55(7):1059-69. DOI: 10.1002/mnfr.201000534. View

10.

Marfella R, Barbieri M, Sardu C, Rizzo M, Siniscalchi M, Paolisso P . Effects of α-lipoic acid therapy on sympathetic heart innervation in patients with previous experience of transient takotsubo cardiomyopathy. J Cardiol. 2015; 67(2):153-61. DOI: 10.1016/j.jjcc.2015.07.012. View

11.

Khera R, Murad M, Chandar A, Dulai P, Wang Z, Prokop L . Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis. JAMA. 2016; 315(22):2424-34. PMC: 5617638. DOI: 10.1001/jama.2016.7602. View

12.

Ansar H, Mazloom Z, Kazemi F, Hejazi N . Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J. 2011; 32(6):584-8. View

13.

Huerta A, Navas-Carretero S, Prieto-Hontoria P, Martinez J, Moreno-Aliaga M . Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. Obesity (Silver Spring). 2015; 23(2):313-21. DOI: 10.1002/oby.20966. View

14.

Ziegler D, Hanefeld M, Ruhnau K, Hasche H, Lobisch M, Schutte K . Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy. Diabetes Care. 1999; 22(8):1296-301. DOI: 10.2337/diacare.22.8.1296. View

15.

Deneke S . Thiol-based antioxidants. Curr Top Cell Regul. 2000; 36:151-80. DOI: 10.1016/s0070-2137(01)80007-8. View

16.

Ratliff J, Palmese L, Reutenauer E, Tek C . An open-label pilot trial of alpha-lipoic acid for weight loss in patients with schizophrenia without diabetes. Clin Schizophr Relat Psychoses. 2013; 8(4):196-200. DOI: 10.3371/CSRP.RAPA.030113. View

17.

Carbonelli M, Di Renzo L, Bigioni M, Di Daniele N, De Lorenzo A, Fusco M . Alpha-lipoic acid supplementation: a tool for obesity therapy?. Curr Pharm Des. 2010; 16(7):840-6. DOI: 10.2174/138161210790883589. View

18.

Manning P, Sutherland W, Williams S, Walker R, Berry E, De Jong S . The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. Nutr Metab Cardiovasc Dis. 2012; 23(6):543-9. DOI: 10.1016/j.numecd.2011.11.006. View

19.

Seo E, Ha A, Kim W . α-Lipoic acid reduced weight gain and improved the lipid profile in rats fed with high fat diet. Nutr Res Pract. 2012; 6(3):195-200. PMC: 3395783. DOI: 10.4162/nrp.2012.6.3.195. View

20.

Evans J, Goldfine I . Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Ther. 2001; 2(3):401-13. DOI: 10.1089/15209150050194279. View