Alpha-lipoic Acid Administration Affects Psychological Status and Markers of Inflammation and Oxidative Damage in Patients with Type 2 Diabetes and Coronary Heart Disease

Overview

Journal J Diabetes Metab Disord

Specialty Endocrinology

Date 2022 Nov 21

PMID 36404866

Authors

Vahidreza Ostadmohammadi

Fariba Raygan

Zatollah Asemi

Affiliations

Soon will be listed here.

Abstract

Background: This investigation was performed to assess the effects of alpha-lipoic acid (ALA) supplementation on psychological status and markers of inflammation and oxidative damage in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD).

Methods: This randomized, double-blind, placebo-controlled trial was performed in 60 patients with T2DM and CHD, aged 45-85 years. Patients were randomized into two groups to receive either 600 mg/day ALA (n = 30) or placebo (n = 30) for 12 weeks.

Results: ALA supplementation significantly decreased Beck Depression Inventory index (BDI) (-5.1 ± 3.5 vs. -1.1 ± 4.8, P = 0.001) when compared with the placebo. ALA supplementation resulted also in a significant reduction of serum high sensitivity C-reactive protein (hs-CRP) (-0.8 ± 1.4 vs. +0.5 ± 0.6 mg/L, P < 0.001) and malondialdehyde (MDA) (-0.3 ± 0.2 vs. -0.1 ± 0.3 µmol/L, P = 0.003), and a significant increase in plasma total antioxidant capacity (TAC) levels (+ 26.8 ± 36.0 vs. -4.6 ± 43.4 mmol/L, P = 0.007) when compared with the placebo. ALA intake upregulated transforming growth factor beta (TGF-β) (P = 0.03) and downregulated gene expression of interleukin-1 (IL-1) (P = 0.001) in peripheral blood mononuclear cells of patients with T2DM and CHD as well.

Conclusions: ALA supplementation for 12 weeks in patients with T2DM and CHD had beneficial effects on BDI, hs-CRP, TAC, MDA values, and gene expression of IL-1 and TGF-β.

Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-022-01031-1.

Citing Articles

Effects of n-3 Polyunsaturated Fatty Acid Supplementation on Cardiovascular Indices in Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials.

Li R, Wang Y, Xu J, Yu J, Li B Rev Cardiovasc Med. 2025; 26(2):25882.

PMID: 40026502 PMC: 11868883. DOI: 10.31083/RCM25882.

References

Beck A, Ward C, Mendelson M, Mock J, ERBAUGH J . An inventory for measuring depression. Arch Gen Psychiatry. 1961; 4:561-71. DOI: 10.1001/archpsyc.1961.01710120031004. View

Musselman D, Miller A, PORTER M, Manatunga A, Gao F, Penna S . Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings. Am J Psychiatry. 2001; 158(8):1252-7. DOI: 10.1176/appi.ajp.158.8.1252. View

Cicero A, Colletti A, Bajraktari G, Descamps O, Djuric D, Ezhov M . Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Nutr Rev. 2017; 75(9):731-767. DOI: 10.1093/nutrit/nux047. View

Golbidi S, Badran M, Laher I . Diabetes and alpha lipoic Acid. Front Pharmacol. 2011; 2:69. PMC: 3221300. DOI: 10.3389/fphar.2011.00069. View

Beck A, Epstein N, Brown G, Steer R . An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988; 56(6):893-7. DOI: 10.1037//0022-006x.56.6.893. View

Chatterjee S, Khunti K, Davies M . Type 2 diabetes. Lancet. 2017; 389(10085):2239-2251. DOI: 10.1016/S0140-6736(17)30058-2. View

Raygan F, Ostadmohammadi V, Asemi Z . The effects of probiotic and selenium co-supplementation on mental health parameters and metabolic profiles in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2018; 38(4):1594-1598. DOI: 10.1016/j.clnu.2018.07.017. View

Rezaei Kelishadi M, Naeini A, Askari G, Khorvash F, Heidari Z . The efficacy of alpha-lipoic acid in improving oxidative, inflammatory, and mood status in women with episodic migraine in a randomised, double-blind, placebo-controlled clinical trial. Int J Clin Pract. 2021; 75(9):e14455. DOI: 10.1111/ijcp.14455. View

Mazloom Z, Ekramzadeh M, Hejazi N . Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: a randomized, single-blind, placebo-controlled trial. Pak J Biol Sci. 2014; 16(22):1597-600. DOI: 10.3923/pjbs.2013.1597.1600. View

10.

Akbari M, Ostadmohammadi V, Tabrizi R, Mobini M, Lankarani K, Moosazadeh M . The effects of alpha-lipoic acid supplementation on inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Nutr Metab (Lond). 2018; 15:39. PMC: 5989440. DOI: 10.1186/s12986-018-0274-y. View

11.

Bierhaus A, Chevion S, Chevion M, Hofmann M, Quehenberger P, Illmer T . Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes. 1997; 46(9):1481-90. DOI: 10.2337/diab.46.9.1481. View

12.

Ali S, Stone M, Peters J, Davies M, Khunti K . The prevalence of co-morbid depression in adults with Type 2 diabetes: a systematic review and meta-analysis. Diabet Med. 2006; 23(11):1165-73. DOI: 10.1111/j.1464-5491.2006.01943.x. View

13.

Hannon-Fletcher M, OKane M, Moles K, Weatherup C, Barnett C, Barnett Y . Levels of peripheral blood cell DNA damage in insulin dependent diabetes mellitus human subjects. Mutat Res. 2000; 460(1):53-60. DOI: 10.1016/s0921-8777(00)00013-6. View

14.

Deslauriers J, Desmarais C, Sarret P, Grignon S . α-Lipoic acid interaction with dopamine D2 receptor-dependent activation of the Akt/GSK-3β signaling pathway induced by antipsychotics: potential relevance for the treatment of schizophrenia. J Mol Neurosci. 2012; 50(1):134-45. DOI: 10.1007/s12031-012-9884-4. View

15.

Maritim A, Sanders R, Watkins 3rd J . Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 2003; 17(1):24-38. DOI: 10.1002/jbt.10058. View

16.

Ainsworth B, Haskell W, Whitt M, Irwin M, Swartz A, Strath S . Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000; 32(9 Suppl):S498-504. DOI: 10.1097/00005768-200009001-00009. View

17.

Buysse D, Reynolds 3rd C, Monk T, BERMAN S, Kupfer D . The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989; 28(2):193-213. DOI: 10.1016/0165-1781(89)90047-4. View

18.

Knol M, Twisk J, Beekman A, Heine R, Snoek F, Pouwer F . Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia. 2006; 49(5):837-45. DOI: 10.1007/s00125-006-0159-x. View

19.

Benzie I, Strain J . The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996; 239(1):70-6. DOI: 10.1006/abio.1996.0292. View

20.

Smith K, Beland M, Clyde M, Gariepy G, Page V, Badawi G . Association of diabetes with anxiety: a systematic review and meta-analysis. J Psychosom Res. 2013; 74(2):89-99. DOI: 10.1016/j.jpsychores.2012.11.013. View