Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products

Overview

Journal Chem Rev

Publisher American Chemical Society

Specialty Chemistry

Date 2017 Mar 16

PMID 28293944

Citations 73

Authors

Zachary G Brill

Matthew L Condakes

Chi P Ting

Thomas J Maimone

Affiliations

Soon will be listed here.

Abstract

The pool of abundant chiral terpene building blocks (i.e., "chiral pool terpenes") has long served as a starting point for the chemical synthesis of complex natural products, including many terpenes themselves. As inexpensive and versatile starting materials, such compounds continue to influence modern synthetic chemistry. This review highlights 21st century terpene total syntheses which themselves use small, terpene-derived materials as building blocks. An outlook to the future of research in this area is highlighted as well.

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