The Application of Proteomics to Traumatic Brain and Spinal Cord Injuries

Overview

Journal Curr Neurol Neurosci Rep

Specialty Neurology

Date 2017 Mar 12

PMID 28283963

Citations 12

Authors

George Anis Sarkis

Manasi D Mangaonkar

Ahmed Moghieb

Brian Lelling

Michael Guertin

Hamad Yadikar

Zhihui Yang

Firas Kobeissy

Kevin K W Wang

Affiliations

Soon will be listed here.

Abstract

Traumatic brain injury (TBI) and traumatic spinal cord injury (SCI), collectively termed neurotrauma, are two parallel neurological conditions that can cause long-lasting neurological impairment and other comorbidities in patients, while at the same time, can create a high burden to society. To date, there are still no FDA-approved therapeutic interventions for either TBI or SCI. Recent advances in proteomic technologies, including tandem mass spectrometry, as well as imaging mass spectrometry, have enabled new approaches to study the differential proteome in TBI and SCI with the use of either animal disease models and/or biosamples from clinical observational studies. Thus, the applications of state-of-the-art proteomic method hold promises in shedding light on identifying clinically useful neurotrauma "biomarkers" and/or in identifying distinct and, otherwise, unobvious systems pathways or "key drivers" that can be further exploited as new therapeutic intervention targets.

Citing Articles

Can repetitive mechanical motion cause structural damage to axons?.

Coppini A, Falconieri A, Mualem O, Nasrin S, Roudon M, Saper G Front Mol Neurosci. 2024; 17:1371738.

PMID: 38912175 PMC: 11191579. DOI: 10.3389/fnmol.2024.1371738.

Sample Preparation Method for MALDI Mass Spectrometry Imaging of Fresh-Frozen Spines.

Bender K, Wang Y, Zhai C, Saenz Z, Wang A, Neumann E Anal Chem. 2023; 95(47):17337-17346.

PMID: 37886878 PMC: 10688227. DOI: 10.1021/acs.analchem.3c03672.

Combined transcriptomics and proteomics forecast analysis for potential biomarker in the acute phase of temporal lobe epilepsy.

Huang C, You Z, He Y, Li J, Liu Y, Peng C Front Neurosci. 2023; 17:1145805.

PMID: 37065920 PMC: 10097945. DOI: 10.3389/fnins.2023.1145805.

Tandem Mass Tag-based proteomics analysis reveals the vital role of inflammation in traumatic brain injury in a mouse model.

Dong J, Ge Q, Lu S, Yang M, Zhuang Y, Zhang B Neural Regen Res. 2022; 18(1):155-161.

PMID: 35799536 PMC: 9241417. DOI: 10.4103/.

A Literature Review of Traumatic Brain Injury Biomarkers.

Ghaith H, Nawar A, Gabra M, Abdelrahman M, Nafady M, Bahbah E Mol Neurobiol. 2022; 59(7):4141-4158.

PMID: 35499796 PMC: 9167167. DOI: 10.1007/s12035-022-02822-6.

References

Grant S . Systems biology in neuroscience: bridging genes to cognition. Curr Opin Neurobiol. 2003; 13(5):577-82. DOI: 10.1016/j.conb.2003.09.016. View

Seeley E, Caprioli R . Molecular imaging of proteins in tissues by mass spectrometry. Proc Natl Acad Sci U S A. 2008; 105(47):18126-31. PMC: 2587620. DOI: 10.1073/pnas.0801374105. View

Norris J, Caprioli R . Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem Rev. 2013; 113(4):2309-42. PMC: 3624074. DOI: 10.1021/cr3004295. View

Yamasaki K, Setoguchi T, Takenouchi T, Yone K, Komiya S . Stem cell factor prevents neuronal cell apoptosis after acute spinal cord injury. Spine (Phila Pa 1976). 2009; 34(4):323-7. DOI: 10.1097/BRS.0b013e318193a1de. View

Whitehead S, Chan K, Gangaraju S, Slinn J, Li J, Hou S . Imaging mass spectrometry detection of gangliosides species in the mouse brain following transient focal cerebral ischemia and long-term recovery. PLoS One. 2011; 6(6):e20808. PMC: 3110773. DOI: 10.1371/journal.pone.0020808. View

Caughlin S, Hepburn J, Park D, Jurcic K, Yeung K, Cechetto D . Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke. PLoS One. 2015; 10(6):e0130364. PMC: 4473074. DOI: 10.1371/journal.pone.0130364. View

Chughtai K, Heeren R . Mass spectrometric imaging for biomedical tissue analysis. Chem Rev. 2010; 110(5):3237-77. PMC: 2907483. DOI: 10.1021/cr100012c. View

Hook G, Jacobsen J, Grabstein K, Kindy M, Hook V . Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate. Front Neurol. 2015; 6:178. PMC: 4557097. DOI: 10.3389/fneur.2015.00178. View

Papurica M, Rogobete A, Sandesc D, Dumache R, Cradigati C, Sarandan M . Advances in Biomarkers in Critical Ill Polytrauma Patients. Clin Lab. 2016; 62(6):977-86. DOI: 10.7754/clin.lab.2015.151103. View

10.

Yan X, Liu J, Luo Z, Ding Q, Mao X, Yan M . Proteomic profiling of proteins in rat spinal cord induced by contusion injury. Neurochem Int. 2010; 56(8):971-83. DOI: 10.1016/j.neuint.2010.04.007. View

11.

Loov C, Shevchenko G, Geeyarpuram Nadadhur A, Clausen F, Hillered L, Wetterhall M . Identification of injury specific proteins in a cell culture model of traumatic brain injury. PLoS One. 2013; 8(2):e55983. PMC: 3567017. DOI: 10.1371/journal.pone.0055983. View

12.

Coles J, Fryer T, Smielewski P, Chatfield D, Steiner L, Johnston A . Incidence and mechanisms of cerebral ischemia in early clinical head injury. J Cereb Blood Flow Metab. 2004; 24(2):202-11. DOI: 10.1097/01.WCB.0000103022.98348.24. View

13.

Roux A, Muller L, Jackson S, Post J, Baldwin K, Hoffer B . Mass spectrometry imaging of rat brain lipid profile changes over time following traumatic brain injury. J Neurosci Methods. 2016; 272:19-32. PMC: 7577232. DOI: 10.1016/j.jneumeth.2016.02.004. View

14.

Alder J, Fujioka W, Lifshitz J, Crockett D, Thakker-Varia S . Lateral fluid percussion: model of traumatic brain injury in mice. J Vis Exp. 2011; (54). PMC: 3217637. DOI: 10.3791/3063. View

15.

Tsai M, Shen L, Kuo H, Cheng H, Chak K . Involvement of acidic fibroblast growth factor in spinal cord injury repair processes revealed by a proteomics approach. Mol Cell Proteomics. 2008; 7(9):1668-87. PMC: 2556019. DOI: 10.1074/mcp.M800076-MCP200. View

16.

Rosenberg G . Matrix metalloproteinases in brain injury. J Neurotrauma. 1995; 12(5):833-42. DOI: 10.1089/neu.1995.12.833. View

17.

Devaux S, Cizkova D, Quanico J, Franck J, Nataf S, Pays L . Proteomic Analysis of the Spatio-temporal Based Molecular Kinetics of Acute Spinal Cord Injury Identifies a Time- and Segment-specific Window for Effective Tissue Repair. Mol Cell Proteomics. 2016; 15(8):2641-70. PMC: 4974342. DOI: 10.1074/mcp.M115.057794. View

18.

Groseclose M, Andersson M, Hardesty W, Caprioli R . Identification of proteins directly from tissue: in situ tryptic digestions coupled with imaging mass spectrometry. J Mass Spectrom. 2007; 42(2):254-62. DOI: 10.1002/jms.1177. View

19.

Franck J, Arafah K, Elayed M, Bonnel D, Vergara D, Jacquet A . MALDI imaging mass spectrometry: state of the art technology in clinical proteomics. Mol Cell Proteomics. 2009; 8(9):2023-33. PMC: 2742436. DOI: 10.1074/mcp.R800016-MCP200. View

20.

Aichler M, Walch A . MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice. Lab Invest. 2015; 95(4):422-31. DOI: 10.1038/labinvest.2014.156. View