Opaque-white Phenotype Transition: a Programmed Morphological Transition in Candida Albicans

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1988 Feb 1

PMID 2828333

Citations 96

Authors

E H Rikkerink

B B Magee

P T Magee

Affiliations

Soon will be listed here.

Abstract

This paper reports that the opaque and white phenotypes of Candida albicans constitute a true high-frequency reversible transition system. The rDNA restriction fragment and orthogonal field alternating gel electrophoresis profiles of opaque and white phenotypes are indistinguishable, and a genetic marker introduced into a white strain is present in all opaque derivatives of this strain. Opaque and white derivatives appear markedly different on a bismuth indicator medium and differ in a number of other respects. We have used bismuth medium to examine the spontaneous and temperature-induced frequencies of transition from opaque to white. The temperature-induced transition from opaque to white does not occur when opaque cells are held in water.

Citing Articles

White-opaque switching in : cell biology, regulation, and function.

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Strain background of interacts with to alter phenotypic switching.

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Variation in transcription regulator expression underlies differences in white-opaque switching between the SC5314 reference strain and the majority of Candida albicans clinical isolates.

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deletion does not have major impacts on white opaque switching, filamentation, or virulence.

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Fun30 nucleosome remodeller regulates white-to-opaque switching in .

Gao N, Dai B, Nie X, Zhao Q, Zhu W, Chen J Acta Biochim Biophys Sin (Shanghai). 2023; 55(3):508-517.

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