The Bovine Leukemia Virus P34 is a Transactivator Protein

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 1987 Nov 1

PMID 2828028

Citations 38

Authors

L Willems

A Gegonne

G Chen

A Burny

R Kettmann

J Ghysdael

Affiliations

Soon will be listed here.

Abstract

Recombinant Moloney murine retroviruses containing the BLV post-envelope long open reading frame were constructed and transfected into the psi 2 packaging cell line. They were shown to encode and to express a 34-kd protein able to transactivate the BLV long terminal repeat-directed gene expression in the respective transfected cells. These data demonstrate that the BLV X-LOR gene encodes a p34 transactivator product. Furthermore, the different cell lines produced infectious recombinant retroviruses capable of transferring X-LOR genes into recipient cells. The availability of the BLV transactivator protein should allow us to understand the role of the transactivator protein in BLV-induced leukemogenesis.

Citing Articles

Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization.

Bellefroid M, Rodari A, Galais M, Krijger P, Tjalsma S, Nestola L Nucleic Acids Res. 2022; 50(6):3190-3202.

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Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome.

Van Driessche B, Rodari A, Delacourt N, Fauquenoy S, Vanhulle C, Burny A Sci Rep. 2016; 6:31125.

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Vaccination against δ-retroviruses: the bovine leukemia virus paradigm.

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Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus.

Aida Y, Murakami H, Takahashi M, Takeshima S Front Microbiol. 2013; 4:328.

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Identification of bovine leukemia virus tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis.

Arainga M, Takeda E, Aida Y BMC Genomics. 2012; 13:121.

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