Understanding Memory CD8 T Cells

Overview

Journal Immunol Lett

Specialty Allergy & Immunology

Date 2017 Mar 10

PMID 28274794

Citations 39

Authors

Tasleem Samji

Kamal M Khanna

Affiliations

Soon will be listed here.

Abstract

Memory CD8 T cells were originally thought to exist as two populations (effector and central memory). In recent years, a third population called resident memory T cells has been discovered and further to this these populations are being divided into different subtypes. Understanding the function and developmental pathways of memory CD8 T cells is key to developing effective therapies against cancer and infectious diseases. Here we have reviewed what is currently known about all three subsets of memory CD8 T populations and as to how each population was originally discovered and the developmental pathways of each subpopulation. Each memory population appears to play a distinct role in adaptive immune responses but we are still a long way from understanding how the populations are generated and what roles they play in protection against invading pathogens and if they contribute to the pathogenesis of inflammatory diseases.

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