Effect of Oxidative Stress on ABC Transporters: Contribution to Epilepsy Pharmacoresistance

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2017 Mar 8

PMID 28264441

Citations 22

Authors

Gurpreet Kaur Grewal

Samiksha Kukal

Neha Kanojia

Luciano Saso

Shrikant Kukreti

Ritushree Kukreti

Affiliations

Soon will be listed here.

Abstract

Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is considered one of the major reasons for pharmacoresistance. In this review, we have summarized the regulation of ABC transporters in response to oxidative stress due to disease and antiepileptic drugs. Further, ketogenic diet and antioxidants were examined for their role in pharmacoresistance. The understanding of signalling pathways and mechanism involved may help in identifying potential therapeutic targets and improving drug response.

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