3/ Drives Aggressive Breast Cancer Progression by Down-regulation of GATA3 Expression

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2017 Mar 5

PMID 28258171

Citations 23

Authors

Payam Shahi

Chih-Yang Wang

Devon A Lawson

Euan M Slorach

Angela Lu

Ying Yu

Ming-Derg Lai

Hugo Gonzalez Velozo

Zena Werb

Affiliations

Soon will be listed here.

Abstract

The transcription factor GATA3 is the master regulator that drives mammary luminal epithelial cell differentiation and maintains mammary gland homeostasis. Loss of is associated with aggressive breast cancer development. We have identified ZNF503/ZEPPO2 zinc-finger elbow-related proline domain protein 2 (ZPO2) as a transcriptional repressor of expression and transcriptional activity that induces mammary epithelial cell proliferation and breast cancer development. We show that ZPO2 is recruited to promoter in association with ZBTB32 (Repressor of GATA, ROG) and that ZBTB32 is essential for down-regulation of via ZPO2. Through this modulation of GATA3 activity, ZPO2 promotes aggressive breast cancer development. Our data provide insight into a mechanism of GATA3 regulation, and identify ZPO2 as a possible candidate gene for future diagnostic and therapeutic strategies.

Citing Articles

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