The Role of APOE on Lipid Homeostasis and Inflammation in Normal Brains

Overview

Journal J Lipid Res

Publisher Elsevier

Specialty Biochemistry

Date 2017 Mar 5

PMID 28258087

Citations 68

Authors

G William Rebeck

Affiliations

Soon will be listed here.

Abstract

The role of APOE in the risk of Alzheimer's disease (AD) has largely focused on its effects on AD pathological processes. However, there are increasing data that genotype affects processes in normal brains. Studies of young cognitively normal humans show effects of genotype on brain structure and activity. Studies of normal knock-in mice show effects of genotype on brain structure, neuronal markers, and behavior. APOE interactions with molecules important for lipid efflux and lipid endocytosis underlie effects of genotype on neuroinflammation and lipoprotein composition. These effects provide important targets for new therapies for reduction of the risk of AD before any signs of pathogenesis.

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