Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress

Overview

Journal Antioxidants (Basel)

Date 2017 Mar 4

PMID 28257114

Citations 5

Authors

Jiang Liu

Yanling Yan

Ying Nie

Joseph I Shapiro

Affiliations

Soon will be listed here.

Abstract

Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling which contributes to long-term blood pressure regulation and have been extensively reviewed. Here we present our progress on the Na/K-ATPase signaling mediated sodium reabsorption in renal proximal tubules, from cardiotonic steroids-mediated to reactive oxygen species (ROS)-mediated Na/K-ATPase signaling that contributes to experimental salt sensitivity.

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