Presynaptic Localization of GluK5 in Rod Photoreceptors Suggests a Novel Function of High Affinity Glutamate Receptors in the Mammalian Retina

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Feb 25

PMID 28235022

Citations 5

Authors

Iris Haumann

Dirk Junghans

Max Anstotz

Michael Frotscher

Affiliations

Soon will be listed here.

Abstract

Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina. Double-immunofluoresence labeling and electron microscopic analysis revealed a presynaptic localization of GluK5 in the outer plexiform layer. Unexpectedly, we found GluK5 almost exclusively localized to the presynaptic ribbon of photoreceptor terminals. Moreover, in GluK5-deficient mutant mice the structural integrity of synaptic ribbons was severely altered pointing to a novel function of GluK5 in organizing synaptic ribbons in the presynaptic terminals of rod photoreceptors.

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