Effects of Klotho Deletion from Bone During Chronic Kidney Disease

Overview

Journal Bone

Specialties Endocrinology
Orthopedics

Date 2017 Feb 25

PMID 28232146

Citations 6

Authors

Jovana Kaludjerovic

Hirotaka Komaba

Beate Lanske

Affiliations

Soon will be listed here.

Abstract

Klotho is a type I transmembrane protein that acts as a permissive co-receptor for FGF23 and helps to maintain proper mineral metabolism. Mice carrying a loss-of-function mutation in either the Klotho or Fgf23 gene develop many similar phenotypes including osteoporosis. Based on these observations it was hypothesized that the bone phenotypes in Klotho- and Fgf23-null mice may be mediated through a common signaling pathway. Recent improvements in antibody specificity have shown that osteoblasts and osteocytes, which produce FGF23, also express low amount of membrane Klotho. But, the role of Klotho in bone is still largely unclear. In this review we summarize the literature and show that Klotho has an FGF23 dependent and independent effect in bone.

Citing Articles

Association of serum Klotho with the severity and mortality among adults with cardiovascular-kidney-metabolic syndrome.

Tang J, Xu Z, Ren L, Xu J, Chen X, Jin Y Lipids Health Dis. 2024; 23(1):408.

PMID: 39695774 PMC: 11654297. DOI: 10.1186/s12944-024-02400-w.

Relationship of the bone phenotype of the Klotho mutant mouse model of accelerated aging to changes in skeletal architecture that occur with chronological aging.

Verlinden L, Li S, Veldurthy V, Carmeliet G, Christakos S Front Endocrinol (Lausanne). 2024; 15:1310466.

PMID: 38352710 PMC: 10861770. DOI: 10.3389/fendo.2024.1310466.

Klotho in Osx-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair.

Fan Y, Cui C, Rosen C, Sato T, Xu R, Li P Signal Transduct Target Ther. 2022; 7(1):155.

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Protective Effects of Moderate Ca Supplementation against Cd-Induced Bone Damage under Different Population-Relevant Doses in Young Female Rats.

Huang X, Liu T, Zhao M, Fu H, Wang J, Xu Q Nutrients. 2019; 11(4).

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Updates in CKD-Associated Osteoporosis.

Khairallah P, Nickolas T Curr Osteoporos Rep. 2018; 16(6):712-723.

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