Long Noncoding RNAs As Novel Serum Biomarkers for the Diagnosis of Hepatocellular Carcinoma: a Systematic Review and Meta-analysis

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2017 Feb 12

PMID 28188488

Citations 20

Authors

C Zheng

H Hao

L Chen

J Shao

Affiliations

Soon will be listed here.

Abstract

Purpose: Long noncoding RNAs (lncRNAs) are outstanding as novel cancer biomarkers with great prospects. Herein, we focused on summarizing the overall diagnostic evaluation of lncRNAs for hepatocellular carcinoma (HCC).

Methods: Relevant literature was collected from the online databases. The Quality Assessment for Studies of Diagnostic Accuracy checklist was used to assess the quality of included studies. The pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were plotted using random-effects models. Summary receiver operating characteristic curve and the area under the curve (AUC) were used to estimate the overall test performance. Statistical analysis was performed by STATA 14.0 and Meta-DiSc 1.4 software.

Results: Ten studies with a total of 820 HCC patients and 785 healthy controls were included. For overall lncRNAs, the pooled sensitivity, specificity, and DOR to predict HCC patients were 80% [95% confidence interval (CI) 77-82%], 79% (95% CI 76-81%), and 27.66 (95% CI 14.26-53.63), respectively, corresponding to an AUC of 0.91.

Conclusions: LncRNAs were a high diagnostic value for HCC and its expression could potentially be used as auxiliary biomarker in confirming HCC.

Citing Articles

Combinatorial Gene Expression Profiling of Serum , , and lncRNAs to Differentiate Hepatocellular Carcinoma from Liver Diseases: A Systematic Review and Meta-Analysis.

Lumkul L, Jantaree P, Jaisamak K, Wongkummool W, Lapisatepun W, Orrapin S Int J Mol Sci. 2024; 25(2).

PMID: 38279264 PMC: 10816616. DOI: 10.3390/ijms25021258.

The paradoxical functions of long noncoding RNAs in hepatocellular carcinoma: Implications in therapeutic opportunities and precision medicine.

Li D, Fan X, Li Y, Yang J, Lin H Genes Dis. 2022; 9(2):358-369.

PMID: 35224152 PMC: 8843871. DOI: 10.1016/j.gendis.2020.11.014.

The impact of LncRNA dysregulation on clinicopathology and survival of pancreatic cancer: a systematic review and meta-analysis (PRISMA compliant).

Hosseini E, Nikkhah A, Sotudeh A, Alizadeh Zarei M, Izadpanah F, Nikzad H Cancer Cell Int. 2021; 21(1):447.

PMID: 34425840 PMC: 8383355. DOI: 10.1186/s12935-021-02125-1.

Long non-coding RNA BCAR4 promotes liver cancer progression by regulating proliferation, migration and invasion.

Wang A, Meng J, Liu H, Li C, Zhou Z Oncol Lett. 2020; 20(3):2779-2787.

PMID: 32782595 PMC: 7400972. DOI: 10.3892/ol.2020.11826.

A Circulating Long Noncoding RNA Panel Serves as a Diagnostic Marker for Hepatocellular Carcinoma.

Huang J, Zheng Y, Xiao X, Liu C, Lin J, Zheng S Dis Markers. 2020; 2020:5417598.

PMID: 32733618 PMC: 7376401. DOI: 10.1155/2020/5417598.

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