Urothelial Cancer Associated 1: a Long Noncoding RNA with a Crucial Role in Cancer

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2015 Sep 6

PMID 26341664

Citations 91

Authors

Mei Xue

Wei Chen

Xu Li

Affiliations

Soon will be listed here.

Abstract

Background: Urothelial cancer associated 1 (UCA1) is a long noncoding RNA (lncRNA) which has gained more attention in recent years due to its aberrant expression in embryogenesis and a broad range of cancer tissues and cells. Importantly, multiple studies have shown that UCA1 plays oncogenic roles in tumor growth and metastasis, and it may act as a potential biomarker and therapeutic target for human cancers. However, the molecular mechanism of UCA1 in cancer initiation, progression and metastasis remains incompletely understood. Thus, gaining a better understanding of the functional mechanism of UCA1 in cancer onset and progression is of the utmost significance for evaluating the potential application of UCA1.

Results And Discussion: In this review, we discuss UCA1 expression profiling, isoform, expression regulation, biological role and mechanism for UCA1 tumor-promoting effect. We further discuss the potential clinical application of UCA1 as a promising diagnostic biomarker or therapeutic target for human cancers.

Conclusion: UCA1 functions as an oncogenic lncRNA in several malignancies, and it might become a potential biomarker or therapeutic target for human cancers.

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