Kidney Organoids: A Translational Journey

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2017 Feb 12

PMID 28188103

Citations 70

Authors

Ryuji Morizane

Joseph V Bonventre

Affiliations

Soon will be listed here.

Abstract

Human pluripotent stem cells (hPSCs) are attractive sources for regenerative medicine and disease modeling in vitro. Directed hPSC differentiation approaches have derived from knowledge of cell development in vivo rather than from stochastic cell differentiation. Moreover, there has been great success in the generation of 3D organ-buds termed 'organoids' from hPSCs; these consist of a variety of cell types in vitro that mimic organs in vivo. The organoid bears great potential in the study of human diseases in vitro, especially when combined with CRISPR/Cas9-based genome-editing. We summarize the current literature describing organoid studies with a special focus on kidney organoids, and discuss goals and future opportunities for organoid-based studies.

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