The Use of Collagen Matrix (Ologen) As a Patch Graft in Glaucoma Tube Shunt Surgery, a Retrospective Chart Review

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2017 Feb 11

PMID 28184280

Citations 6

Authors

John D Stephens

Steven R Sarkisian Jr

Affiliations

Soon will be listed here.

Abstract

To determine the safety and efficacy of collagen matrix as a patch graft in glaucoma drainage surgery. Collagen matrix grafts may be advantageous because they do not need to be harvested from human donors. An institutional, retrospective review of 43 patients with at least 12 months follow-up status post-glaucoma drainage implant surgery were evaluated for signs of tube erosion after initial placement of collagen matrix patch graft. Forty-one of 43 eyes (95.3%) required no intervention for patch graft melting with tube erosion. Average time of follow-up was 32 months (range: 12-45). Two cases had tube erosion at 4 months and 26 months post-op requiring tube revision, which was successfully revised with conjunctiva (4 month erosion) and donor sclera (26 month erosion). Our results suggest that collagen matrix patch grafts may be used successfully as a patch graft in glaucoma tube shunt surgery, and may be advantageous because they do not have to be harvested from human donors. It is possible that exposure rates may be higher after longer follow-up and with larger numbers of patients. Further research is needed to compare Ologen to traditional graft materials to conclusively determine the safety and efficacy of collagen matrix as a novel patch graft material.

Citing Articles

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Trabeculectomy with subconjunctival collagen implant in Indian eyes: Long-term results.

Singh K, Bhattacharyya M, Mutreja A, Dangda S Indian J Ophthalmol. 2018; 66(10):1429-1434.

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Patch graft using collagen matrix (Ologen) for glaucoma drainage device exposure in a patient with Boston Keratoprosthesis type 1.

Jabbour S, Lesk M, Harissi-Dagher M Am J Ophthalmol Case Rep. 2018; 12:32-35.

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Patch Grafting Using an Ologen Collagen Matrix to Manage Tubal Exposure in Glaucoma Tube Shunt Surgery.

Tanito M, Sano I, Ikeda Y, Fujihara E Case Rep Ophthalmol. 2018; 9(1):9-16.

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Conjunctival repair after glaucoma drainage device exposure using collagen-glycosaminoglycane matrices.

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