Expression and Prognostic Significance of Zinc Fingers and Homeoboxes Family Members in Renal Cell Carcinoma

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Feb 3

PMID 28152006

Citations 22

Authors

Ryuk-Jun Kwon

Yun Hak Kim

Dae Cheon Jeong

Myoung-Eun Han

Ji-Young Kim

Liangwen Liu

Jin-Sup Jung

Sae-Ock Oh

Affiliations

Soon will be listed here.

Abstract

Zinc fingers and homeoboxes (ZHX) is a transcription repressor family that contains three members; ZHX1, ZHX2, and ZHX3. Although ZHX family members have been associated with the progression of cancer, their values as prognostic factors in cancer patients have been poorly examined. Renal cell carcinoma (RCC) is a highly heterogeneous, aggressive cancer that responds variably to treatment. Thus, prognostic molecular markers are required to evaluate disease progression and to improve the survival. In clear cell RCC (ccRCC), ZHX1 and ZHX3 expression were found to be down-regulated but ZHX2 was up-regulated, and the expressions of ZHX1 and ZHX3 were significantly associated with pathological stage. Furthermore, Kaplan-Meier and multivariate regression analysis showed that reduction in the mRNA expression of ZHX1 was associated with poorer survival. Taken together, the present study shows loss of ZHX1 is correlated with ccRCC progression and suggests it is an independent prognostic marker in ccRCC.

Citing Articles

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