Host Transcription Factors in Hepatitis B Virus RNA Synthesis

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2020 Feb 6

PMID 32019103

Citations 41

Authors

Kristi L Turton

Vanessa Meier-Stephenson

Maulik D Badmalia

Carla S Coffin

Trushar R Patel

Affiliations

Soon will be listed here.

Abstract

The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the nucleus. As HBV replication requires the help of host transcription factors to replicate, focusing on host protein-HBV genome interactions may reveal insights into new drug targets against cccDNA. The structural details on such complexes, however, remain poorly defined. In this review, the current literature regarding host transcription factors' interactions with HBV cccDNA is discussed.

Citing Articles

Tristetraprolin Family Members and Processing Bodies: A Complex Regulatory Network Involved in Fatty Liver Disease, Viral Hepatitis and Hepatocellular Carcinoma.

Gellee N, Legrand N, Jouve M, Devaux P, Dubuquoy L, Sobolewski C Cancers (Basel). 2025; 17(3).

PMID: 39941720 PMC: 11815756. DOI: 10.3390/cancers17030348.

Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene.

Zhang M, Mouzannar K, Zhang Z, Teraoka Y, Piotrowski J, Ishida Y PLoS Pathog. 2025; 21(1):e1012803.

PMID: 39787208 PMC: 11717313. DOI: 10.1371/journal.ppat.1012803.

DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication.

Ren C, Zhang Z, Dou Y, Sun Y, Fu Z, Wang L Adv Sci (Weinh). 2024; 11(48):e2409485.

PMID: 39498874 PMC: 11672287. DOI: 10.1002/advs.202409485.

Identification and characterization of host factor VCPIP1 as a multi-functional positive regulator of hepatitis B virus.

Kang N, Liu N, Liu M, Zhang S, Yang Y, Hou J J Virol. 2024; 98(12):e0158124.

PMID: 39494904 PMC: 11650987. DOI: 10.1128/jvi.01581-24.

Solamargine acts as an antiviral by interacting to MZF1 and targeting the core promoter of the hepatitis B virus gene.

Chen W, Zhao X, Huang Y, Lu K, Li Y, Li X Aging (Albany NY). 2024; 16(15):11668-11682.

PMID: 39133152 PMC: 11346786. DOI: 10.18632/aging.206047.

References

Garrison W, Battle M, Yang C, Kaestner K, Sladek F, Duncan S . Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology. 2006; 130(4):1207-20. PMC: 3581272. DOI: 10.1053/j.gastro.2006.01.003. View

Dubuquoy L, Louvet A, Hollebecque A, Mathurin P, Dharancy S . Peroxisome proliferator-activated receptors in HBV-related infection. PPAR Res. 2009; 2009:145124. PMC: 2667936. DOI: 10.1155/2009/145124. View

Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris T . Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature. 2008; 456(7220):350-6. PMC: 2743566. DOI: 10.1038/nature07413. View

Takiguchi M . The C/EBP family of transcription factors in the liver and other organs. Int J Exp Pathol. 1999; 79(6):369-91. PMC: 3220372. DOI: 10.1046/j.1365-2613.1998.00082.x. View

Stergiopoulos A, Elkouris M, Politis P . Prospero-related homeobox 1 (Prox1) at the crossroads of diverse pathways during adult neural fate specification. Front Cell Neurosci. 2015; 8:454. PMC: 4306308. DOI: 10.3389/fncel.2014.00454. View

Lu C, Yen T . Activation of the hepatitis B virus S promoter by transcription factor NF-Y via a CCAAT element. Virology. 1996; 225(2):387-94. DOI: 10.1006/viro.1996.0613. View

Zhang H, Ables E, Pope C, Washington M, Hipkens S, Means A . Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev. 2009; 126(11-12):958-73. PMC: 2783291. DOI: 10.1016/j.mod.2009.09.006. View

Lucifora J, Protzer U . Attacking hepatitis B virus cccDNA--The holy grail to hepatitis B cure. J Hepatol. 2016; 64(1 Suppl):S41-S48. DOI: 10.1016/j.jhep.2016.02.009. View

Vizcaino C, Mansilla S, Portugal J . Sp1 transcription factor: A long-standing target in cancer chemotherapy. Pharmacol Ther. 2015; 152:111-24. DOI: 10.1016/j.pharmthera.2015.05.008. View

10.

Yumoto F, Nguyen P, Sablin E, Baxter J, Webb P, Fletterick R . Structural basis of coactivation of liver receptor homolog-1 by β-catenin. Proc Natl Acad Sci U S A. 2011; 109(1):143-8. PMC: 3252924. DOI: 10.1073/pnas.1117036108. View

11.

Galloway N, Ball K, Stiff T, Wall N . Yin Yang 1 (YY1): Regulation of Survivin and Its Role In Invasion and Metastasis. Crit Rev Oncog. 2018; 22(1-2):23-36. PMC: 6108429. DOI: 10.1615/CritRevOncog.2017020836. View

12.

Ramiere C, Scholtes C, Diaz O, Icard V, Perrin-Cocon L, Trabaud M . Transactivation of the hepatitis B virus core promoter by the nuclear receptor FXRalpha. J Virol. 2008; 82(21):10832-40. PMC: 2573182. DOI: 10.1128/JVI.00883-08. View

13.

Bar-Yishay I, Shaul Y, Shlomai A . Hepatocyte metabolic signalling pathways and regulation of hepatitis B virus expression. Liver Int. 2011; 31(3):282-90. DOI: 10.1111/j.1478-3231.2010.02423.x. View

14.

van de Putte T, Francis A, Nelles L, van Grunsven L, Huylebroeck D . Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome. Hum Mol Genet. 2007; 16(12):1423-36. DOI: 10.1093/hmg/ddm093. View

15.

Takashima M, Ogawa W, Hayashi K, Inoue H, Kinoshita S, Okamoto Y . Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. Diabetes. 2010; 59(7):1608-15. PMC: 2889759. DOI: 10.2337/db09-1679. View

16.

Benson G, Nguyen T, Maas R . The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes. Mol Cell Biol. 1995; 15(3):1591-601. PMC: 230383. DOI: 10.1128/MCB.15.3.1591. View

17.

Vieler M, Sanyal S . p53 Isoforms and Their Implications in Cancer. Cancers (Basel). 2018; 10(9). PMC: 6162399. DOI: 10.3390/cancers10090288. View

18.

Kang L, Choi Y, Lee S . Stimulation of TRAF6/TAK1 degradation and inhibition of JNK/AP-1 signalling by ginsenoside Rg3 attenuates hepatitis B virus replication. Int J Biochem Cell Biol. 2013; 45(11):2612-21. DOI: 10.1016/j.biocel.2013.08.016. View

19.

Lau H, Ng N, Loo L, Jasmen J, Teo A . The molecular functions of hepatocyte nuclear factors - In and beyond the liver. J Hepatol. 2017; 68(5):1033-1048. DOI: 10.1016/j.jhep.2017.11.026. View

20.

Jiang H, Yu J, Guo H, Song H, Chen S . Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells. Biochem Biophys Res Commun. 2008; 368(1):1-5. DOI: 10.1016/j.bbrc.2007.04.004. View