A Detailed View on 1,8-cineol Biosynthesis by

Overview

Journal Beilstein J Org Chem

Specialty Chemistry

Date 2017 Feb 2

PMID 28144299

Citations 11

Authors

Jan Rinkel

Patrick Rabe

Laura Zur Horst

Jeroen S Dickschat

Affiliations

Soon will be listed here.

Abstract

The stereochemical course of the cyclisation reaction catalysed by the bacterial 1,8-cineol synthase from was investigated using stereospecifically deuterated substrates. In contrast to the well investigated plant enzyme from , the reaction proceeds via ()-linalyl diphosphate and the ()-terpinyl cation, while the final cyclisation reaction is in both cases a addition, as could be shown by incubation of (2-C)geranyl diphosphate in deuterium oxide.

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