Neutrophils Promote Hepatic Metastasis Growth Through Fibroblast Growth Factor 2-dependent Angiogenesis in Mice

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2017 Jan 31

PMID 28133764

Citations 74

Authors

Alex N Gordon-Weeks

Su Y Lim

Arseniy E Yuzhalin

Keaton Jones

Bostjan Markelc

K Jin Kim

Jon N Buzzelli

Emmanouil Fokas

Yunhong Cao

Sean Smart

Ruth Muschel

Affiliations

Soon will be listed here.

Abstract

Conclusion: Here, we show, using FGF2 as an example, that identification of factors responsible for the protumoral effects of infiltrating myeloid cells can be used to target established liver metastases. Such therapies could be utilized to limit disease progression and potentiate the effects of standard ablative therapies. (Hepatology 2017;65:1920-1935).

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