IL-5 Blocks Apoptosis and Tau Hyperphosphorylation Induced by Aβ Peptide in PC12 Cells

Overview

Journal J Physiol Biochem

Specialties Biochemistry
Physiology

Date 2017 Jan 30

PMID 28132394

Citations 7

Authors

Yuanyuan Zhou

Chaoyan Li

Deheng Li

Yaping Zheng

Jin Wang

Affiliations

Soon will be listed here.

Abstract

The primary features of Alzheimer's disease (AD) are extracellular amyloid plaques consisting mainly of deposits of amyloid β (Aβ) peptides and intracellular neurofibrillary tangles (NFTs). Sets of evidence suggest that interleukin-5 (IL-5) is involved in the pathogenesis of AD. Herein, we investigated the protective role of IL-5 in PC12 cells, to provide new insights into understanding this disease. Western blot was employed to assess the protein levels of Bax and phospho-tau as well as phospho-JAK2; MTT assay was performed to decipher cell viability. Treatment of IL-5 decreased Aβ-induced tau phosphorylation and apoptosis, effects blunted by JAK2 inhibition. IL-5 prevents Aβ-evoked tau protein hyperphosphorylation and apoptosis through JAK2 signaling.

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