Advanced Imaging in Acute and Chronic Deep Vein Thrombosis

Overview

Journal Cardiovasc Diagn Ther

Publisher AME Publishing Company

Specialty Cardiology & Vascular Diseases

Date 2017 Jan 27

PMID 28123971

Citations 53

Authors

Gita Yashwantrao Karande

Sandeep S Hedgire

Yadiel Sanchez

Vinit Baliyan

Vishala Mishra

Suvranu Ganguli

Anand M Prabhakar

Affiliations

Soon will be listed here.

Abstract

Deep venous thrombosis (DVT) affecting the extremities is a common clinical problem. Prompt imaging aids in rapid diagnosis and adequate treatment. While ultrasound (US) remains the workhorse of detection of extremity venous thrombosis, CT and MRI are commonly used as the problem-solving tools either to visualize the thrombosis in central veins like superior or inferior vena cava (IVC) or to test for the presence of complications like pulmonary embolism (PE). The cross-sectional modalities also offer improved visualization of venous collaterals. The purpose of this article is to review the established modalities used for characterization and diagnosis of DVT, and further explore promising innovations and recent advances in this field.

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References

Goodman L, Gulsun M, Nagy P, Washington L . CT of deep venous thrombosis and pulmonary embolus: does iso-osmolar contrast agent improve vascular opacification?. Radiology. 2005; 234(3):923-8. DOI: 10.1148/radiol.2343031871. View

Fraser D, Moody A, Morgan P, Martel A, Davidson I . Diagnosis of lower-limb deep venous thrombosis: a prospective blinded study of magnetic resonance direct thrombus imaging. Ann Intern Med. 2002; 136(2):89-98. DOI: 10.7326/0003-4819-136-2-200201150-00006. View

Kalva S, Jagannathan J, Hahn P, Wicky S . Venous thromboembolism: indirect CT venography during CT pulmonary angiography--should the pelvis be imaged?. Radiology. 2008; 246(2):605-11. DOI: 10.1148/radiol.2462070319. View

Spritzer C, Arata M, Freed K . Isolated pelvic deep venous thrombosis: relative frequency as detected with MR imaging. Radiology. 2001; 219(2):521-5. DOI: 10.1148/radiology.219.2.r01ma25521. View

Spritzer C, Sostman H, Wilkes D, Coleman R . Deep venous thrombosis: experience with gradient-echo MR imaging in 66 patients. Radiology. 1990; 177(1):235-41. DOI: 10.1148/radiology.177.1.2399324. View

Rubin J, Xie H, Kim K, Weitzel W, Emelianov S, Aglyamov S . Sonographic elasticity imaging of acute and chronic deep venous thrombosis in humans. J Ultrasound Med. 2006; 25(9):1179-86. DOI: 10.7863/jum.2006.25.9.1179. View

Kelly J, Rudd A, Lewis R, Hunt B . Plasma D-dimers in the diagnosis of venous thromboembolism. Arch Intern Med. 2002; 162(7):747-56. DOI: 10.1001/archinte.162.7.747. View

Rubin J, Aglyamov S, Wakefield T, ODonnell M, Emelianov S . Clinical application of sonographic elasticity imaging for aging of deep venous thrombosis: preliminary findings. J Ultrasound Med. 2003; 22(5):443-8. DOI: 10.7863/jum.2003.22.5.443. View

Loud P, Katz D, Bruce D, Klippenstein D, Grossman Z . Deep venous thrombosis with suspected pulmonary embolism: detection with combined CT venography and pulmonary angiography. Radiology. 2001; 219(2):498-502. DOI: 10.1148/radiology.219.2.r01ma26498. View

10.

Carpenter J, Holland G, Baum R, Owen R, Carpenter J, Cope C . Magnetic resonance venography for the detection of deep venous thrombosis: comparison with contrast venography and duplex Doppler ultrasonography. J Vasc Surg. 1993; 18(5):734-41. DOI: 10.1067/mva.1993.49364. View

11.

Phinikaridou A, Andia M, Saha P, Modarai B, Smith A, Botnar R . In vivo magnetization transfer and diffusion-weighted magnetic resonance imaging detects thrombus composition in a mouse model of deep vein thrombosis. Circ Cardiovasc Imaging. 2013; 6(3):433-440. PMC: 3983477. DOI: 10.1161/CIRCIMAGING.112.000077. View

12.

Wu C, Jong S . Radionuclide venography of lower limbs by subcutaneous injection: comparison with venography by intravenous injection. Ann Nucl Med. 1989; 3(3):125-33. DOI: 10.1007/BF03178298. View

13.

Thomas S, Goodacre S, Sampson F, van Beek E . Diagnostic value of CT for deep vein thrombosis: results of a systematic review and meta-analysis. Clin Radiol. 2008; 63(3):299-304. DOI: 10.1016/j.crad.2007.09.010. View

14.

Kim T, Murakami T, Hori M, Kumano S, Sakon M, Nakamura H . Efficacy of multi-slice helical CT venography for the diagnosis of deep venous thrombosis: comparison with venous sonography. Radiat Med. 2004; 22(2):77-81. View

15.

Lee Y . Current developments in imaging for deep vein thrombosis. Hong Kong Med J. 2015; 21(2):96-7. DOI: 10.12809/hkmj154545. View

16.

Tan Y, da Silva A . Digital photoplethysmography in the diagnosis of suspected lower limb DVT: is it useful?. Eur J Vasc Endovasc Surg. 1999; 18(1):71-9. DOI: 10.1053/ejvs.1999.0886. View

17.

Kanne J, Lalani T . Role of computed tomography and magnetic resonance imaging for deep venous thrombosis and pulmonary embolism. Circulation. 2004; 109(12 Suppl 1):I15-21. DOI: 10.1161/01.CIR.0000122871.86662.72. View

18.

Moser K, Fedullo P, LitteJohn J, Crawford R . Frequent asymptomatic pulmonary embolism in patients with deep venous thrombosis. JAMA. 1994; 271(3):223-5. View

19.

Cho E, Chung J, Kim S, Kim J, Yu J, Yoon C . CT venography for deep vein thrombosis using a low tube voltage (100 kVp) setting could increase venous enhancement and reduce the amount of administered iodine. Korean J Radiol. 2013; 14(2):183-93. PMC: 3590329. DOI: 10.3348/kjr.2013.14.2.183. View

20.

Kearon C, Akl E, Ornelas J, Blaivas A, Jimenez D, Bounameaux H . Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report. Chest. 2016; 149(2):315-352. DOI: 10.1016/j.chest.2015.11.026. View