PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium Tuberculosis

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2017 Jan 26

PMID 28119467

Citations 49

Authors

Avishek Mitra

Alexander Speer

Kan Lin

Sabine Ehrt

Michael Niederweis

Affiliations

Soon will be listed here.

Abstract

Importance: Tuberculosis is caused by Mycobacterium tuberculosis and is a devastating disease affecting eight million people each year. Iron is an essential nutrient for replication of M. tuberculosis in the human host. More than 70% of iron in the human body is bound in heme. Not surprisingly, many bacterial pathogens, including M. tuberculosis, are able to acquire iron from heme. However, the mechanism of heme uptake by M. tuberculosis is poorly understood. We have identified two novel surface proteins that bind heme and are required for heme utilization by M. tuberculosis These findings constitute a major advancement of our understanding of iron acquisition by M. tuberculosis and show that M. tuberculosis has evolved heme uptake systems different from the paradigms established by other bacteria.

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