Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation

Overview

Journal Endocrinol Metab (Seoul)

Specialty Endocrinology

Date 2017 Jan 25

PMID 28116872

Citations 14

Authors

Minsang Shin

Hye Suk Kang

Jae Hyung Park

Jae Hoon Bae

Dae Kyu Song

Seung Soon Im

Affiliations

Soon will be listed here.

Abstract

Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.

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References

Clemmons D, Snyder D, Busby Jr W . Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects. J Clin Endocrinol Metab. 1991; 73(4):727-33. DOI: 10.1210/jcem-73-4-727. View

Lynch G, Cuffe S, Plant D, Gregorevic P . IGF-I treatment improves the functional properties of fast- and slow-twitch skeletal muscles from dystrophic mice. Neuromuscul Disord. 2001; 11(3):260-8. DOI: 10.1016/s0960-8966(00)00192-9. View

Schoen T, Mazuruk K, Waldbillig R, Potts J, Beebe D, Chader G . Cloning and characterization of a chick embryo cDNA and gene for IGF-binding protein-2. J Mol Endocrinol. 1995; 15(1):49-59. DOI: 10.1677/jme.0.0150049. View

Chua C, Liu Y, Granberg K, Hu L, Haapasalo H, Annala M . IGFBP2 potentiates nuclear EGFR-STAT3 signaling. Oncogene. 2015; 35(6):738-47. PMC: 4615268. DOI: 10.1038/onc.2015.131. View

Levi J, Huynh F, Denroche H, Neumann U, Glavas M, Covey S . Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice. Diabetologia. 2011; 55(3):752-62. DOI: 10.1007/s00125-011-2426-8. View

Rehfeldt C, Renne U, Sawitzky M, Binder G, Hoeflich A . Increased fat mass, decreased myofiber size, and a shift to glycolytic muscle metabolism in adolescent male transgenic mice overexpressing IGFBP-2. Am J Physiol Endocrinol Metab. 2010; 299(2):E287-98. DOI: 10.1152/ajpendo.00492.2009. View

Clemmons D . The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity. J Clin Invest. 2004; 113(1):25-7. PMC: 300772. DOI: 10.1172/JCI20660. View

Tombolan L, Orso F, Guzzardo V, Casara S, Zin A, Bonora M . High IGFBP2 expression correlates with tumor severity in pediatric rhabdomyosarcoma. Am J Pathol. 2011; 179(5):2611-24. PMC: 3204033. DOI: 10.1016/j.ajpath.2011.07.018. View

La P, Schnepp R, Petersen C, Silva A, Hua X . Tumor suppressor menin regulates expression of insulin-like growth factor binding protein 2. Endocrinology. 2004; 145(7):3443-50. PMC: 2858565. DOI: 10.1210/en.2004-0124. View

10.

Johnson M, Gonzalez de Mejia E . Phenolic Compounds from Fermented Berry Beverages Modulated Gene and Protein Expression To Increase Insulin Secretion from Pancreatic β-Cells in Vitro. J Agric Food Chem. 2016; 64(12):2569-81. DOI: 10.1021/acs.jafc.6b00239. View

11.

Kibbey M, Jameson M, Eaton E, Rosenzweig S . Insulin-like growth factor binding protein-2: contributions of the C-terminal domain to insulin-like growth factor-1 binding. Mol Pharmacol. 2005; 69(3):833-45. DOI: 10.1124/mol.105.016998. View

12.

Li Z, Miard S, Laplante M, Sonenberg N, Picard F . Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway. Mol Cell Endocrinol. 2012; 358(1):63-8. DOI: 10.1016/j.mce.2012.02.022. View

13.

Feldser D, Agani F, Iyer N, Pak B, Ferreira G, Semenza G . Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res. 1999; 59(16):3915-8. View

14.

Schertzer J, van der Poel C, Shavlakadze T, Grounds M, Lynch G . Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice. Am J Physiol Cell Physiol. 2007; 294(1):C161-8. DOI: 10.1152/ajpcell.00399.2007. View

15.

Heald A, Kaushal K, Siddals K, Rudenski A, Anderson S, Gibson J . Insulin-like growth factor binding protein-2 (IGFBP-2) is a marker for the metabolic syndrome. Exp Clin Endocrinol Diabetes. 2006; 114(7):371-6. DOI: 10.1055/s-2006-924320. View

16.

Kang H, Cho H, Lee J, Oh G, Koo S, Park B . Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states. Sci Rep. 2016; 6:23665. PMC: 4806307. DOI: 10.1038/srep23665. View

17.

Renehan A, Frystyk J, Flyvbjerg A . Obesity and cancer risk: the role of the insulin-IGF axis. Trends Endocrinol Metab. 2006; 17(8):328-36. DOI: 10.1016/j.tem.2006.08.006. View

18.

Pannett A, Thakker R . Multiple endocrine neoplasia type 1. Endocr Relat Cancer. 2000; 6(4):449-73. DOI: 10.1677/erc.0.0060449. View

19.

Mireuta M, Darnel A, Pollak M . IGFBP-2 expression in MCF-7 cells is regulated by the PI3K/AKT/mTOR pathway through Sp1-induced increase in transcription. Growth Factors. 2010; 28(4):243-55. DOI: 10.3109/08977191003745472. View

20.

Allen R, Boxhorn L . Regulation of skeletal muscle satellite cell proliferation and differentiation by transforming growth factor-beta, insulin-like growth factor I, and fibroblast growth factor. J Cell Physiol. 1989; 138(2):311-5. DOI: 10.1002/jcp.1041380213. View