Teriparatide Versus Low-dose Bisphosphonates Before and After Surgery for Adult Spinal Deformity in Female Japanese Patients with Osteoporosis

Overview

Journal Eur Spine J

Specialty Orthopedics

Date 2017 Jan 25

PMID 28116510

Citations 28

Authors

Shoji Seki

Norikazu Hirano

Yoshiharu Kawaguchi

Masato Nakano

Taketoshi Yasuda

Kayo Suzuki

Kenta Watanabe

Hiroto Makino

Masahiko Kanamori

Tomoatsu Kimura

Affiliations

Soon will be listed here.

Abstract

Purpose: Complications of adult spinal deformity surgery are problematic in osteoporotic individuals. We compared outcomes between Japanese patients treated perioperatively with teriparatide vs. low-dose bisphosphonates.

Methods: Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion. Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age. Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.

Results: Adjacent vertebral fractures and implant failure, fusion failure, and poor pain and ODI outcomes were significantly more common in the bisphosphonates group than the teriparatide group.

Conclusions: Perioperative administration of teriparatide is more effective than that of low-dose bisphosphonates in preventing complications and maintaining fusion rates in osteoporotic Japanese females with spinal deformities undergoing surgery.

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