The Lignicolous Fungus Trametes Versicolor (L.) Lloyd (1920): a Promising Natural Source of Antiradical and AChE Inhibitory Agents

Overview

Journal J Enzyme Inhib Med Chem

Specialty Biochemistry

Date 2017 Jan 19

PMID 28097907

Citations 25

Authors

Ljiljana Janjusevic

Maja Karaman

Filip Sibul

Giuseppina Tommonaro

Carmine Iodice

Dragica Jakovljevic

Boris Pejin

Affiliations

Soon will be listed here.

Abstract

This study aimed to determine antiradical (DPPH and OH) and acetylcholinesterase (AChE) inhibitory activities along with chemical composition of autochtonous fungal species Trametes versicolor (Serbia). A total of 38 phenolic compounds with notable presence of phenolic acids were identified using HPLC/MS-MS. Its water extract exhibited the highest antiradical activity against OH (3.21 μg/mL), among the rest due to the presence of gallic, p-coumaric and caffeic acids. At the concentration of 100 μg/mL, the same extract displayed a profound AChE inhibitory activity (60.53%) in liquid, compared to donepezil (89.05%), a drug in clinical practice used as positive control. The flavonoids baicalein and quercetin may be responsible compounds for the AChE inhibitory activity observed. These findings have demonstrated considerable potential of T. versicolor water extract as a natural source of antioxidant(s) and/or AChE inhibitor(s) to be eventually used as drug-like compounds or food supplements in the treatment of Alzheimer's disease.

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