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Evolutionary Dynamics of Pandemic Methicillin-Sensitive Staphylococcus Aureus ST398 and Its International Spread Via Routes of Human Migration

Overview
Journal mBio
Publisher American Society for Microbiology
Specialty Microbiology
Date 2017 Jan 19
PMID 28096484
Citations 32
Authors
Anne-Catrin Uhlemann
Paul R McAdam
Sean B Sullivan
Justin R Knox
Hossein Khiabanian
Raul Rabadan
Peter R Davies
J Ross Fitzgerald
Franklin D Lowy
Affiliations
Soon will be listed here.
Abstract

Importance: Unlike methicillin-resistant Staphylococcus aureus (MRSA), surprisingly little is known about the clonal evolution of methicillin-susceptible S. aureus (MSSA), although these strains account for the majority of S. aureus infections. To better understand how MSSA spreads and becomes established in communities, we applied comparative bacterial whole-genome sequencing to pandemic ST398-MSSA, a clone of clinical importance affecting humans and livestock in different geographic regions. Phylogeographic analyses identified that ST398-MSSA spread along local cultural and migratory links between parts of the Caribbean, North America, and France, respectively. We observed high within-host SNP variability compared to our previous studies on the dominant MRSA clone USA300. Our data indicate that the dynamics of colonization, persistence, and transmission differ substantially between USA300 MRSA and ST398 MSSA.

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