THE RETINOBLASTOMA PROTEIN: A MASTER TUMOR SUPPRESSOR ACTS AS A LINK BETWEEN CELL CYCLE AND CELL ADHESION

Overview

Journal Cell Health Cytoskelet

Publisher Dove Medical Press

Specialty Cell Biology

Date 2017 Jan 17

PMID 28090172

Citations 14

Authors

B E Engel

W D Cress

P G Santiago-Cardona

Affiliations

Soon will be listed here.

Abstract

was the first tumor suppressor gene discovered. Over four decades of work have revealed that the Rb protein (pRb) is a master regulator of biological pathways influencing virtually every aspect of intrinsic cell fate including cell growth, cell-cycle checkpoints, differentiation, senescence, self-renewal, replication, genomic stability and apoptosis. While these many processes may account for a significant portion of 's potency as a tumor suppressor, a small, but growing stream of evidence suggests that also significantly influences how a cell interacts with its environment, including cell-to-cell and cell-to-extracellular matrix interactions. This review will highlight pRb's role in the control of cell adhesion and how alterations in the adhesive properties of tumor cells may drive the deadly process of metastasis.

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