Blockade of Serotonin 5-HT Receptors Suppresses Behavioral Sensitization and Naloxone-Precipitated Withdrawal Symptoms in Morphine-Treated Mice

Overview

Journal Front Pharmacol

Date 2017 Jan 14

PMID 28082900

Citations 16

Authors

Gang Pang

Xian Wu

Xinrong Tao

Ruoying Mao

Xueke Liu

Yong-Mei Zhang

Guangwu Li

Robert W Stackman Jr

Liuyi Dong

Gongliang Zhang

Affiliations

Soon will be listed here.

Abstract

Highlights: (i)Blockade of 5-HT receptors suppresses the expression of morphine-induced behavioral sensitization.(ii)Blockade of 5-HT receptors suppresses naloxone-precipitated withdrawal in morphine-treated mice.(iii)Chronic morphine exposure induces an increase in 5-HT receptor protein level and a decrease in ERK protein phosphorylation in prefrontal cortex.

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