Recent Advances on Smart TiO Nanotube Platforms for Sustainable Drug Delivery Applications

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2017 Jan 6

PMID 28053530

Citations 32

Authors

Qun Wang

Jian-Ying Huang

Hua-Qiong Li

Allan Zi-Jian Zhao

Yi Wang

Ke-Qin Zhang

Hong-Tao Sun

Yue-Kun Lai

Affiliations

Soon will be listed here.

Abstract

To address the limitations of traditional drug delivery, TiO nanotubes (TNTs) are recognized as a promising material for localized drug delivery systems. With regard to the excellent biocompatibility and physicochemical properties, TNTs prepared by a facile electrochemical anodizing process have been used to fabricate new drug-releasing implants for localized drug delivery. This review discusses the development of TNTs applied in localized drug delivery systems, focusing on several approaches to control drug release, including the regulation of the dimensions of TNTs, modification of internal chemical characteristics, adjusting pore openings by biopolymer coatings, and employing polymeric micelles as drug nanocarriers. Furthermore, rational strategies on external conditions-triggered stimuli-responsive drug release for localized drug delivery systems are highlighted. Finally, the review concludes with the recent advances on TNTs for controlled drug delivery and corresponding prospects in the future.

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References

Santos A, Sinn Aw M, Bariana M, Kumeria T, Wang Y, Losic D . Drug-releasing implants: current progress, challenges and perspectives. J Mater Chem B. 2020; 2(37):6157-6182. DOI: 10.1039/c4tb00548a. View

Ge M, Cao C, Li S, Tang Y, Wang L, Qi N . In situ plasmonic Ag nanoparticle anchored TiO2 nanotube arrays as visible-light-driven photocatalysts for enhanced water splitting. Nanoscale. 2016; 8(9):5226-34. DOI: 10.1039/c5nr08341a. View

Sinn Aw M, Khalid K, Gulati K, Atkins G, Pivonka P, Findlay D . Characterization of drug-release kinetics in trabecular bone from titania nanotube implants. Int J Nanomedicine. 2012; 7:4883-92. PMC: 3446838. DOI: 10.2147/IJN.S33655. View

Park J, Koak J, Jang J, Han C, Kim S, Heo S . Osseointegration of anodized titanium implants coated with fibroblast growth factor-fibronectin (FGF-FN) fusion protein. Int J Oral Maxillofac Implants. 2006; 21(6):859-66. View

Chen B, Lu K . Hierarchically branched titania nanotubes with tailored diameters and branch numbers. Langmuir. 2011; 28(5):2937-43. DOI: 10.1021/la204154h. View

Savonitto S, DUrbano M, Caracciolo M, Barlocco F, Mariani G, Nichelatti M . Urgent surgery in patients with a recently implanted coronary drug-eluting stent: a phase II study of 'bridging' antiplatelet therapy with tirofiban during temporary withdrawal of clopidogrel. Br J Anaesth. 2010; 104(3):285-91. DOI: 10.1093/bja/aep373. View

Simovic S, Losic D, Vasilev K . Controlled drug release from porous materials by plasma polymer deposition. Chem Commun (Camb). 2010; 46(8):1317-9. DOI: 10.1039/b919840g. View

Sirivisoot S, Pareta R, Webster T . A conductive nanostructured polymer electrodeposited on titanium as a controllable, local drug delivery platform. J Biomed Mater Res A. 2011; 99(4):586-97. DOI: 10.1002/jbm.a.33210. View

Kayser O, Lemke A, Hernandez-Trejo N . The impact of nanobiotechnology on the development of new drug delivery systems. Curr Pharm Biotechnol. 2005; 6(1):3-5. DOI: 10.2174/1389201053167158. View

10.

LaVan D, McGuire T, Langer R . Small-scale systems for in vivo drug delivery. Nat Biotechnol. 2003; 21(10):1184-91. DOI: 10.1038/nbt876. View

11.

Peer D, Karp J, Hong S, Farokhzad O, Margalit R, Langer R . Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2008; 2(12):751-60. DOI: 10.1038/nnano.2007.387. View

12.

Li H, Lai Y, Huang J, Tang Y, Yang L, Chen Z . Multifunctional wettability patterns prepared by laser processing on superhydrophobic TiO nanostructured surfaces. J Mater Chem B. 2020; 3(3):342-347. DOI: 10.1039/c4tb01814a. View

13.

Son S, Bai X, Lee S . Inorganic hollow nanoparticles and nanotubes in nanomedicine Part 1. Drug/gene delivery applications. Drug Discov Today. 2007; 12(15-16):650-6. DOI: 10.1016/j.drudis.2007.06.002. View

14.

Albu S, Kim D, Schmuki P . Growth of aligned TiO2 bamboo-type nanotubes and highly ordered nanolace. Angew Chem Int Ed Engl. 2008; 47(10):1916-9. DOI: 10.1002/anie.200704144. View

15.

Ajami E, Aguey-Zinsou K . Functionalization of electropolished titanium surfaces with silane-based self-assembled monolayers and their application in drug delivery. J Colloid Interface Sci. 2012; 385(1):258-67. DOI: 10.1016/j.jcis.2012.07.005. View

16.

Gulati K, Kant K, Findlay D, Losic D . Periodically tailored titania nanotubes for enhanced drug loading and releasing performances. J Mater Chem B. 2020; 3(12):2553-2559. DOI: 10.1039/c4tb01882f. View

17.

Sinn Aw M, Kurian M, Losic D . Non-eroding drug-releasing implants with ordered nanoporous and nanotubular structures: concepts for controlling drug release. Biomater Sci. 2020; 2(1):10-34. DOI: 10.1039/c3bm60196j. View

18.

Liu L, Yong K, Roy I, Law W, Ye L, Liu J . Bioconjugated pluronic triblock-copolymer micelle-encapsulated quantum dots for targeted imaging of cancer: in vitro and in vivo studies. Theranostics. 2012; 2(7):705-13. PMC: 3418931. DOI: 10.7150/thno.3456. View

19.

Klumpp C, Kostarelos K, Prato M, Bianco A . Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics. Biochim Biophys Acta. 2005; 1758(3):404-12. DOI: 10.1016/j.bbamem.2005.10.008. View

20.

Sirivisoot S, Pareta R, Webster T . Electrically controlled drug release from nanostructured polypyrrole coated on titanium. Nanotechnology. 2011; 22(8):085101. DOI: 10.1088/0957-4484/22/8/085101. View