A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System

Overview

Journal J Neurosci

Specialty Neurology

Date 2017 Jan 6

PMID 28053035

Citations 185

Authors

Vincent Beliveau

Melanie Ganz

Ling Feng

Brice Ozenne

Liselotte Hojgaard

Patrick M Fisher

Claus Svarer

Douglas N Greve

Gitte M Knudsen

Affiliations

Soon will be listed here.

Abstract

Significance Statement: We present a high-resolution positron emission tomography (PET)- and magnetic resonance imaging-based human brain atlas of important serotonin receptors and the transporter. The regional PET-derived binding measures correlate strongly with the corresponding autoradiography protein levels. The strong correlation enables the transformation of the PET-derived human brain atlas into a protein density map of the serotonin (5-hydroxytryptamine, 5-HT) system. Next, we compared the regional receptor/transporter protein densities with mRNA levels and uncovered unique associations between protein expression and density at high detail. This new in vivo neuroimaging atlas of the 5-HT system not only provides insight in the human brain's regional protein synthesis, transport, and density, but also represents a valuable source of information for the neuroscience community as a comparative instrument to assess brain disorders.

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