Deep Brain Stimulation Frequency of the Subthalamic Nucleus Affects Phonemic and Action Fluency in Parkinson's Disease

Overview

Journal Parkinsons Dis

Publisher Wiley

Date 2017 Jan 5

PMID 28050309

Citations 6

Authors

Valeria de Carvalho Fagundes

Carlos R M Rieder

Aline Nunes da Cruz

Barbara Costa Beber

Mirna Wetters Portuguez

Affiliations

Soon will be listed here.

Abstract

Deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) has been linked to a decline in verbal fluency. The decline can be attributed to surgical effects, but the relative contributions of the stimulation parameters are not well understood. This study aimed to investigate the impact of the frequency of STN-DBS on the performance of verbal fluency tasks in patients with PD. Twenty individuals with PD who received bilateral STN-DBS were evaluated. Their performances of verbal fluency tasks (semantic, phonemic, action, and unconstrained fluencies) upon receiving low-frequency (60 Hz) and high-frequency (130 Hz) STN-DBS were assessed. The performances of phonemic and action fluencies were significantly different between low- and high-frequency STN-DBS. Patients showed a decrease in these verbal fluencies for high-frequency STN-DBS. Low-frequency STN-DBS may be less harmful to the verbal fluency of PD patients.

Citing Articles

Speech, voice, and language outcomes following deep brain stimulation: A systematic review.

Tabari F, Berger J, Flouty O, Copeland B, Greenlee J, Johari K PLoS One. 2024; 19(5):e0302739.

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Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease.

Del Bene V, Martin R, Brinkerhoff S, Olson J, Nelson M, Marotta D Ann Neurol. 2024; 95(6):1205-1219.

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Effects of Deep Brain Stimulation in the Subthalamic Nucleus on Neurocognitive Function in Patients With Parkinson's Disease Compared With Medical Therapy: A Meta-Analysis.

Wang J, Pan R, Cui Y, Wang Z, Li Q Front Neurol. 2021; 12:610840.

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Deep brain stimulation effects on verbal fluency dissociated by target and active contact location.

John K, Wylie S, Dawant B, Rodriguez W, Phibbs F, Bradley E Ann Clin Transl Neurol. 2021; 8(3):613-622.

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Sui Y, Tian Y, Ko W, Wang Z, Jia F, Horn A Front Neurol. 2021; 11:597451.

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References

Tomlinson C, Stowe R, Patel S, Rick C, Gray R, Clarke C . Systematic review of levodopa dose equivalency reporting in Parkinson's disease. Mov Disord. 2010; 25(15):2649-53. DOI: 10.1002/mds.23429. View

Xie T, Vigil J, MacCracken E, Gasparaitis A, Young J, Kang W . Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD. Neurology. 2014; 84(4):415-20. PMC: 4336001. DOI: 10.1212/WNL.0000000000001184. View

Abrantes do Amaral R, Malbergiera A . [Evaluation of a screening test for alcohol-related problems (CAGE) among employees of the Campus of the University of São Paulo]. Braz J Psychiatry. 2005; 26(3):156-63. DOI: 10.1590/s1516-44462004000300005. View

Mikos A, Bowers D, Noecker A, McIntyre C, Won M, Chaturvedi A . Patient-specific analysis of the relationship between the volume of tissue activated during DBS and verbal fluency. Neuroimage. 2010; 54 Suppl 1:S238-46. PMC: 2908727. DOI: 10.1016/j.neuroimage.2010.03.068. View

Ehlen F, Krugel L, Vonberg I, Schoenecker T, Kuhn A, Klostermann F . Intact lexicon running slowly--prolonged response latencies in patients with subthalamic DBS and verbal fluency deficits. PLoS One. 2013; 8(11):e79247. PMC: 3827350. DOI: 10.1371/journal.pone.0079247. View

Witt K, Granert O, Daniels C, Volkmann J, Falk D, van Eimeren T . Relation of lead trajectory and electrode position to neuropsychological outcomes of subthalamic neurostimulation in Parkinson's disease: results from a randomized trial. Brain. 2013; 136(Pt 7):2109-19. DOI: 10.1093/brain/awt151. View

Vigliocco G, Vinson D, Druks J, Barber H, Cappa S . Nouns and verbs in the brain: a review of behavioural, electrophysiological, neuropsychological and imaging studies. Neurosci Biobehav Rev. 2010; 35(3):407-26. DOI: 10.1016/j.neubiorev.2010.04.007. View

Piatt A, Fields J, Paolo A, Koller W, Troster A . Lexical, semantic, and action verbal fluency in Parkinson's disease with and without dementia. J Clin Exp Neuropsychol. 1999; 21(4):435-43. DOI: 10.1076/jcen.21.4.435.885. View

Hughes A, Daniel S, Kilford L, Lees A . Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992; 55(3):181-4. PMC: 1014720. DOI: 10.1136/jnnp.55.3.181. View

10.

Schwartz S, Baldo J, Graves R, Brugger P . Pervasive influence of semantics in letter and category fluency: a multidimensional approach. Brain Lang. 2003; 87(3):400-11. DOI: 10.1016/s0093-934x(03)00141-x. View

11.

Merola A, Rizzi L, Zibetti M, Artusi C, Montanaro E, Angrisano S . Medical therapy and subthalamic deep brain stimulation in advanced Parkinson's disease: a different long-term outcome?. J Neurol Neurosurg Psychiatry. 2013; 85(5):552-9. DOI: 10.1136/jnnp-2013-305271. View

12.

Beber B, Chaves M . Does previous presentation of verbal fluency tasks affect verb fluency performance?. Dement Neuropsychol. 2017; 10(1):31-36. PMC: 5674911. DOI: 10.1590/S1980-57642016DN10100006. View

13.

Brucki S, Nitrini R, Caramelli P, Bertolucci P, Okamoto I . [Suggestions for utilization of the mini-mental state examination in Brazil]. Arq Neuropsiquiatr. 2003; 61(3B):777-81. DOI: 10.1590/s0004-282x2003000500014. View

14.

Harati A, Muller T . Neuropsychological effects of deep brain stimulation for Parkinson's disease. Surg Neurol Int. 2013; 4(Suppl 6):S443-7. PMC: 3858804. DOI: 10.4103/2152-7806.121637. View

15.

Borden A, Wallon D, Lefaucheur R, Derrey S, Fetter D, Verin M . Does early verbal fluency decline after STN implantation predict long-term cognitive outcome after STN-DBS in Parkinson's disease?. J Neurol Sci. 2014; 346(1-2):299-302. DOI: 10.1016/j.jns.2014.07.063. View

16.

Brucki S, Rocha M . Category fluency test: effects of age, gender and education on total scores, clustering and switching in Brazilian Portuguese-speaking subjects. Braz J Med Biol Res. 2004; 37(12):1771-7. DOI: 10.1590/s0100-879x2004001200002. View

17.

Troster A, Woods S, Fields J . Verbal fluency declines after pallidotomy: an interaction between task and lesion laterality. Appl Neuropsychol. 2003; 10(2):69-75. DOI: 10.1207/S15324826AN1002_02. View

18.

Machado T, Fichman H, Santos E, Carvalho V, Fialho P, Koenig A . Normative data for healthy elderly on the phonemic verbal fluency task - FAS. Dement Neuropsychol. 2017; 3(1):55-60. PMC: 5619033. DOI: 10.1590/S1980-57642009DN30100011. View

19.

Hooper C, Bakish D . An examination of the sensitivity of the six-item Hamilton Rating Scale for Depression in a sample of patients suffering from major depressive disorder. J Psychiatry Neurosci. 2000; 25(2):178-84. PMC: 1408065. View

20.

Brucki S, Malheiros S, Okamoto I, Bertolucci P . [Normative data on the verbal fluency test in the animal category in our milieu]. Arq Neuropsiquiatr. 1997; 55(1):56-61. DOI: 10.1590/s0004-282x1997000100009. View