Neuropsychological Effects of Deep Brain Stimulation for Parkinson's Disease

Overview

Journal Surg Neurol Int

Specialty Neurology

Date 2013 Dec 19

PMID 24349868

Citations 9

Authors

Ali Harati

Thomas Muller

Affiliations

Soon will be listed here.

Abstract

Background: Putative changes of cognition after deep brain stimulation (DBS) in patients with Parkinson's disease (PD) are a matter of debate. The aim of this study was to assess cognitive abilities before and following bilateral subthalamic nucleus (STN) DBS and to review the available literature.

Methods: Twenty patients underwent bilateral DBS of the STN. Cognitive skills were assessed in a standardized fashion before and at least at 12 months after the surgical intervention.

Results: There was a significant decline of both semantic and phonematic verbal fluency and a mild trend for a deterioration of verbal memory after DBS. Mood, general cognitive screening, and visospatial abilities remained unchanged.

Conclusion: STN DBS in the treatment of PD has resulted in a significant reduction of motor symptoms and improved independence and quality of life in appropriately selected patients. However, it may have isolatable effects on verbal fluency and related function. Case series in the literature reported similar findings. Potential candidates for DBS should be counseled about the risk of mild cognitive declines.

Citing Articles

Differential Cognitive Effects of Unilateral Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease.

Del Bene V, Martin R, Brinkerhoff S, Olson J, Nelson M, Marotta D Ann Neurol. 2024; 95(6):1205-1219.

PMID: 38501317 PMC: 11102318. DOI: 10.1002/ana.26903.

Differential cognitive effects of unilateral left and right subthalamic nucleus deep brain stimulation for Parkinson disease.

Del Bene V, Martin R, Brinkerhoff S, Olson J, Nelson M, Marotta D medRxiv. 2023; .

PMID: 36909562 PMC: 10002774. DOI: 10.1101/2023.02.27.23286478.

Surgical Advances in Parkinson's Disease.

Hvingelby V, Pavese N Curr Neuropharmacol. 2022; 22(6):1033-1046.

PMID: 36411569 PMC: 10964101. DOI: 10.2174/1570159X21666221121094343.

Deep brain stimulation effects on verbal fluency dissociated by target and active contact location.

John K, Wylie S, Dawant B, Rodriguez W, Phibbs F, Bradley E Ann Clin Transl Neurol. 2021; 8(3):613-622.

PMID: 33596331 PMC: 7951101. DOI: 10.1002/acn3.51304.

Recent Clinical Advances in Pharmacotherapy for Levodopa-Induced Dyskinesia.

Muller T, Mohr J Drugs. 2019; 79(13):1367-1374.

PMID: 31332769 DOI: 10.1007/s40265-019-01170-5.

References

Bronstein J, Tagliati M, Alterman R, Lozano A, Volkmann J, Stefani A . Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol. 2010; 68(2):165. PMC: 4523130. DOI: 10.1001/archneurol.2010.260. View

Merola A, Zibetti M, Angrisano S, Rizzi L, Ricchi V, Artusi C . Parkinson's disease progression at 30 years: a study of subthalamic deep brain-stimulated patients. Brain. 2011; 134(Pt 7):2074-84. DOI: 10.1093/brain/awr121. View

Aybek S, Gronchi-Perrin A, Berney A, Catalano Chiuve S, Villemure J, Burkhard P . Long-term cognitive profile and incidence of dementia after STN-DBS in Parkinson's disease. Mov Disord. 2007; 22(7):974-81. DOI: 10.1002/mds.21478. View

Folstein M, ROBINS L, Helzer J . The Mini-Mental State Examination. Arch Gen Psychiatry. 1983; 40(7):812. DOI: 10.1001/archpsyc.1983.01790060110016. View

Okun M, Fernandez H, Wu S, Kirsch-Darrow L, Bowers D, Bova F . Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial. Ann Neurol. 2009; 65(5):586-95. PMC: 2692580. DOI: 10.1002/ana.21596. View

Muller H, Horn R, Helmstaedter C, Elger C . Rey Auditory-Verbal Learning Test: structure of a modified German version. J Clin Psychol. 1997; 53(7):663-71. DOI: 10.1002/(sici)1097-4679(199711)53:7<663::aid-jclp4>3.0.co;2-j. View

Freund H, Kuhn J, Lenartz D, Mai J, Schnell T, Klosterkoetter J . Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation. Arch Neurol. 2009; 66(6):781-5. DOI: 10.1001/archneurol.2009.102. View

Troster A, Fields J, Testa J, Paul R, Blanco C, Hames K . Cortical and subcortical influences on clustering and switching in the performance of verbal fluency tasks. Neuropsychologia. 1998; 36(4):295-304. DOI: 10.1016/s0028-3932(97)00153-x. View

Saez-Zea C, Escamilla-Sevilla F, Katati M, Minguez-Castellanos A . Cognitive effects of subthalamic nucleus stimulation in Parkinson's disease: a controlled study. Eur Neurol. 2012; 68(6):361-6. DOI: 10.1159/000341380. View

10.

Perozzo P, Rizzone M, Bergamasco B, Castelli L, Lanotte M, Tavella A . Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: comparison of pre- and postoperative neuropsychological evaluation. J Neurol Sci. 2001; 192(1-2):9-15. DOI: 10.1016/s0022-510x(01)00575-5. View

11.

Shulman K . Clock-drawing: is it the ideal cognitive screening test?. Int J Geriatr Psychiatry. 2000; 15(6):548-61. DOI: 10.1002/1099-1166(200006)15:6<548::aid-gps242>3.0.co;2-u. View

12.

Smeding H, Speelman J, Huizenga H, Schuurman P, Schmand B . Predictors of cognitive and psychosocial outcome after STN DBS in Parkinson's Disease. J Neurol Neurosurg Psychiatry. 2009; 82(7):754-60. DOI: 10.1136/jnnp.2007.140012. View

13.

Beck A, Ward C, Mendelson M, Mock J, ERBAUGH J . An inventory for measuring depression. Arch Gen Psychiatry. 1961; 4:561-71. DOI: 10.1001/archpsyc.1961.01710120031004. View

14.

Lehrl S, Triebig G, Fischer B . Multiple choice vocabulary test MWT as a valid and short test to estimate premorbid intelligence. Acta Neurol Scand. 1995; 91(5):335-45. DOI: 10.1111/j.1600-0404.1995.tb07018.x. View

15.

Woods S, Troster A . Prodromal frontal/executive dysfunction predicts incident dementia in Parkinson's disease. J Int Neuropsychol Soc. 2003; 9(1):17-24. DOI: 10.1017/s1355617703910022. View

16.

Merola A, Zibetti M, Angrisano S, Rizzi L, Lanotte M, Lopiano L . Comparison of subthalamic nucleus deep brain stimulation and Duodopa in the treatment of advanced Parkinson's disease. Mov Disord. 2011; 26(4):664-70. DOI: 10.1002/mds.23524. View

17.

Castelli L, Perozzo P, Zibetti M, Crivelli B, Morabito U, Lanotte M . Chronic deep brain stimulation of the subthalamic nucleus for Parkinson's disease: effects on cognition, mood, anxiety and personality traits. Eur Neurol. 2006; 55(3):136-44. DOI: 10.1159/000093213. View

18.

Ellrichmann G, Harati A, Muller T . Deep brain stimulation improves performance of complex instrumental paradigms. Eur Neurol. 2008; 60(1):32-6. DOI: 10.1159/000127977. View

19.

Smeding H, Speelman J, Koning-Haanstra M, Schuurman P, Nijssen P, van Laar T . Neuropsychological effects of bilateral STN stimulation in Parkinson disease: a controlled study. Neurology. 2006; 66(12):1830-6. DOI: 10.1212/01.wnl.0000234881.77830.66. View

20.

Jahanshahi M, Ardouin C, Brown R, Rothwell J, Obeso J, Albanese A . The impact of deep brain stimulation on executive function in Parkinson's disease. Brain. 2000; 123 ( Pt 6):1142-54. DOI: 10.1093/brain/123.6.1142. View